Synthesis, spectroscopic characterization, biological screening and in vitro cytotoxic studies of 4‐methyl‐3‐thiosemicarbazone derived Schiff bases and their Co (II), Ni (II), Cu (II) and Zn (II) complexes

Abstract

A series of twenty compounds inclusive of bidentate Schiff bases derived from condensation of 4‐methyl‐3‐thiosemicarbazide with substituted derivatives of napthaldehyde/benzaldehyde/salicylaldehyde and their mononuclear Co (II), Ni (II), Cu (II) and Zn (II) complexes in molar ratio (1:1) were synthesized and characterized. The coordination behavior, modes of bonding and overall geometry of the compounds was known from the elemental analysis, spectral techniques (IR, UV–Vis, 1H NMR, 13C NMR, ESR and ESI‐mass), magnetic moment measurements, molar conductance, thermal and powder XRD studies. The studies revealed octahedral geometry for all the complexes where ligands coordinated in a neutral bidentate manner (NS) via nitrogen atom of azomethine group and sulphur atom of thione group with the metal centre. In vitro biological effects of the compounds were tested against four bacterial species and two fungal strains. The results indicated that the metal complexes showed a marked enhancement in biocidal activity in comparable with the parent Schiff bases. In vitro anticancer activity against the malignant tumor cell lines; human alveolar adenocarcinoma epithelial cell line (A549), human breast adenocarcinoma cell line (MCF7), human prostate cancer cell line (DU145) and human normal lung cell line (MRC‐5) using MTT assay, exposed compound 16 as a leading member with lowest IC50 value of 10.6 ± 0.14 μM against (A549) cell line.

Synthesis, In Silico Study, and Anti-Cancer Activity of Thiosemicarbazone Derivatives

“…In recent years, derivatives of thiosemicarbazones have demonstrated a broad range of biological and pharmacological activities (viz. antifungal, anticancer, antimicrobial, and antiviral) [32][33][34][35][36][37][38][39][40][41]. In line with this, we found no research on the in silico ADMET and drug-likeness prediction, as well as the anticancer activity of the same compound presented in our study.…”

Binuclear Co(II), Ni(II) and Cu(II) Complexes of a new Bis(tridentate) Hydrazone Ligand: Synthesis, Thermal, Spectroscopic, Biological, Molecular Docking and Theoretical Studies

“…Naphthaldehyde-based compounds have numerous presentations such as electrochemical, catalytic, photoluminescence, analytical, cytotoxic, antimicrobial and in vitro anticancer, antiproliferative, antioxidant, catechol's studies [33][34][35][36][37][38][39][40][41][42][43] Transition metal compounds play important role in bio-inorganic chemistry and redox enzyme systems [44]. Copper is one of the most important elements in the human body.…”

Evaluation of anti-tuberculosis activity of some oxotitanium(IV) Schiff base complexes; molecular docking, dynamics simulation and ADMET studies

“…Due to the simple synthesis method, coordination variety, catalytic, medicinal and biological applications Schiff base ligands and their metal complexes achieved much attention [6]. Many of the Schiff base metal complexes act as antifungal, antibacterial [7], antiviral [8], herbicidal [9], analgesic [10], anti-inflammation [11,12], antioxidant [6,13], antitumor [14,15], anticancer [16,17], antitubercular [18][19][20] agent. Previously, many investigations have been demonstrated that, Schiff base with aromatic and hetarocyclic ring coordinated with transitional metals show potential activity against MTB and different microorganisms [18,[20][21][22][23][24], suggesting new possible candidate to break the resistant of MTB.…”