Synthesis, Spectroscopic Characterization and X-Ray Analysis of 6-Nitroquinazoline-2,4(1h,3h)-Dione

Abstract

In this work, 6-nitroquinazoline-2,4(1H,3H)-dione was obtained in two step with good yields using a facile synthetic method. Its structure was characterized by X-ray single crystal diffraction technique (XRD), IR, 1D-NMR ( 1 H-NMR and 13 C-NMR) and 2D-NMR (H-H COSY and H-C HMBC) spectroscopy. All N and O carbonyl atoms are involved in hydrogen bonding, with an average H···O distance of 1.89 (2)

Indole Glycosides from <i>Calanthe discolor</i> with Proliferative Activity on Human Hair Follicle Dermal Papilla Cells

“…31) As shown in Table 1, the methanol extract (5.85% from fresh material) of the fresh underground part of C. discolor also showed significant proliferative effects on HFDPC (% of control: 120.8 ± 0.2%) at 100 µg/mL. From the extract, a new indole glycoside 6′-O-β-D-apiofuranosylindican (1, 0.00016% from the fresh plant material) was isolated along with six known compounds, indican 2,3) (2, 0.00080%), glucoindican 2,3) (3, 0.00018%), calanthoside 2,3) (4, 0.00015%), quinazoline-2,4dione 32) (5, 0.00035%), tryptanthrin 33) (6, 0.000048%), and loroglossol 34) (7, 0.000035%) (Fig. 1).…”

Modulation of platelet functions by Careya sphaerica Roxb. leave extracts

“…[ 10 ] 6-nitro-1H-quinazoline-2,4-dione is quinazoline derivatives which possess anti-inflammatory and antiviral properties. [ 11 12 ] 2-chloroethyl thiocyanate can be used for anti-inflammatory and antimicrobial action to boost the host's defense system while reducing tissue inflammation. [ 13 ] 1-methyl-2-phenyl-1H-indole is a novel compound used for dementia disorders treatment.…”