Synthesis, spectroscopic characterization and pharmacological studies on novel sulfamethaxazole based azo dyes

Synthesis, Characterization and Biological Studies on 3d-Metal Complexes of 5-[(1, 5-Dimethyl-3-oxo-2-Phenyl-2, 3-Dihydro-1H-Pyrazol-4-yl) Diazenyl]-1-Ethyl-6-Hydroxy-4-Methyl-2-oxo-1, 2-Dihydropyridine-3-Carbonitrile

“…we have synthesized a ligand derived from 4-amino antipyrine by simple diazo-coupling method in an acidic medium at lower temperature. It is a simple, convenient and economical method of electrophilic substitution reaction between an aromatic amine with a strong nucleophile in acidic medium at 0-5 o C as described in earlier reports [25][26][27][28][29][30][31]. An accurately weighed 0.002 mol solution of 4-aminoantipyrine (1) in dilute HCl was added to the cold solution of the NaNO 2 in 2 mL H 2 SO 4 with constant stirring at 0-5 o C for 2 h. Then, the formed diazonium salt solution was slowly added to the previously cooled solution of a coupling component ethylpyridone (2) (0.002 mol) in 5 mL aqueous KOH and stirred for another 2 h at the same temperature.…”

“…The thermogram of all the metal complexes exhibited rst step of decomposition in the temperature range 220-303 o C suggesting the quite appreciable thermal stability and con rms the absence of lattice/coordinated water molecules.The thermogram of the copper complex showed 4 steps of degradation with the decomposition temperature 220, 404, 509 and 620 o C with mass loss of 6.75% (calc. 6.62%),31.5% (calc. 31.69%), 14.30% (calc.…”

Analysis of Relationship Between Some Disazo Dyes Derived from 2,4-Dihydroxyquinoline and Its Anticancer and DNA Binding Properties by Density Functional Theory

“…In addition, dyes using 2-aminothiazole compounds having different substituents at the 4-position of analog derivatives as diazo components have been reported to show bathochromic shifts relative to similar dyes derived from benzenoid compounds [17][18][19][20][21]. Moreover, the presence of biological properties of the heterocyclic groups that bind to the dyes was also found to have an effect [22][23][24]. Biological effects of pyrazole [25], pyrimidine [26], thiadiazole [27], quinoline [28] derivatives have been studied by many researchers in the literature.…”

“…Contrary to what is thought, synthetic dyes are known to be used in many fields such as textile [1], paper [2], cosmetics [3], food [4], plastic [5], and pharmaceutical [6][7][8]. Azo dyes constitute the largest and most diverse group in synthetic dyes class and have been the subject of many studies, especially in the fields of biology and pharmacology [9][10][11][12].…”

Synthesis & Characterization Of Azo Compounds Containing Disubstituted Phenolic Moities

“…[4][5] Some azo dye possess medicinal properties like antiseptic, antiprotzoal, antifungal, antibacterial and dyes antipyretic properties. [6][7][8][9] Azo dyes are the largest & most important class of organic dyestuffs. These are the compounds consisting of a -N=N-linkage connected to phenyl ring 10 .…”