Synthesis, Spectroscopic Characterization and Antitumour Activity of Diorganotin(IV) Derivatives of N‐Substituted Ortho‐Aminobenzoic Acid

Abstract

Summary Four compounds of the type [ ( o -R N H -C , H~C O O ) ( C H~C H~C H~C H~)~S~]~O and [(o-CH3NH-CgHqCOO)(CH3)2Sn]120 have been prepared, characterized by 'H, 13C, ' 19Sn NMR, and by Mbssbauer and mass spectrometry. They have been tested in vifro against two human tumour cell lines, nl. MCF-7 (mammary tumour) and WiDr (colon carcinoma), and found to score slightly better than cis-platin but markedly less than other cytostatic agents. lntroductlonWe recently described the synthesis, characterization and antitumour activity of diorganotinbis(orthoaminobenzoates) and of some of their N-substituted derivatives('). They appeared to be more active in vitro than cis-platin against MCF-7 and gave IDs0 values comparable to those obtained for cis-platin against WiDr. Therefore we decided to prepare some corresponding bis(ortho-aminobenzoatodi-nbutyltin) oxides. Results and discussionThe compounds prepared are listed in chart 1 -367 -

Anticancer potential of poly(2-aminobenzoic acid)-blend-Aloe vera against the human breast cancer cell line MDA-MB-231

“…Derivatives of p-amino benzoic acid, 43,44 N-substituted orthoaminobenzoic acid, 45 N-methyl substituted p-aminobenzoic acid 46 are reported to have potential anticancer activities. Aloe-vera is a well-known herb known for its antimicrobial, antioxidant, anti-inflammatory, and anticancer activities.…”

Effect of diorganotin(IV) carboxylate complexes, [N‐(2‐carboxyphenyl) salicylideneiminato]dimethyltin(IV), bis(µ3‐oxo)bis(µ‐O‐aminobenzoato‐O,O′) bis(O‐aminobenzoato)tetrakis[dimethyltin(IV)] and bis(O‐aminobenzoato‐O,O′) di‐n‐butyltin(IV), on the membrane of Candida albicans cells—a mechanistic investigation of the antifungal activity of organotin complexes

“…Compound 3 has been screened and showed remarkable in vitro antitumor activity against the human tumor cell lines, MCF-7 (mammary tumor) and WiDr (colon carcinoma). [27] …”