Synthesis, spectroscopic characterization and antibacterial activity of new cobalt(II) complexes of unsymmetrical tetradentate (OSN2) Schiff base ligands

Saghatforoush, Lotfali; Chalabian, F; Aminkhani, Ali; Karim‐Nezhad, Ghasem; Ershad, Sohrab

doi:10.1016/j.ejmech.2009.06.015

Cited by 80 publications

(39 citation statements)

References 27 publications

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“…2. SpN-1, SpN-2, and SpN-3 shows a strong absorption in the 1,633-1,640 cm -1 range in their IR spectra which are characteristic of the azomethine m(C=N) group [15,16]. In the Schiff base complexes; this absorption has been shifted to the 1,626-1,615 cm -1 region indicating the coordination of the Schiff bases through the nitrogen atom [17,18].…”

Section: Ftirmentioning

confidence: 99%

Synthesized of Sporopollenin-Immobilized Schiff Bases and Their Vanadium(IV) Sorption Studies

Koçak

Şahi̇n

Gübbük

2012

J Inorg Organomet Polym

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This study investigated the potential use of a biologic polymer Lycopodium clavatum spores (Sporopollenin) for removal of vanadium ions (V(IV)) from aqueous solution. Three Schiff base derivative compounds immobilized sporopollenin were prepared and characterized. Immobilized sporopollenin was characterized via a scanning electron microscope, elemental analysis, infrared spectroscopy and thermal analysis techniques. The sorption capacities of the immobilized surfaces toward V(IV) ions were investigated by batch sorption experiments. V(IV) concentration, initial pH and the temperature effects were studied. The isotherm data of V(IV) ions were correlated reasonably well both Langmuir, Freundlich sorption isotherm. The thermodynamic studies showed that the V(IV) sorption onto immobilized sporopollenin derivatives is a spontaneous, endothermic and a chemical reaction.

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Section: Ftirmentioning

confidence: 99%

Synthesized of Sporopollenin-Immobilized Schiff Bases and Their Vanadium(IV) Sorption Studies

Koçak

Şahi̇n

Gübbük

2012

J Inorg Organomet Polym

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“…In this context, the use of simple Co-containing systems with low molecular weight ligands is useful for understanding the correlation between spectroscopic and structural properties (Cowan 1997). Many complexes of Co(II) showing antimicrobial activity had been synthesized recently (López-Sandoval et al 2008;Saghatforoush et al 2009;Rodríguez-Argüelles et al 2009), even with sulfonamides as ligands (Ö zdemir et al 2009). …”

Section: Introductionmentioning

confidence: 98%

Synthesis, characterization and antimicrobial properties of a Co(II)-phthalylsulfathiazolate complex

et al. 2010

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The reaction between phthalylsulfathiazole (H(2)PST), in alkaline aqueous solution, and cobalt(II) nitrate led to a pink solid, [Co(PST)(H(2)O)(4)] (1), which was characterized by elemental and thermogravimetric analysis; FT-IR, Raman and diffuse reflectance spectra. Spectroscopic data reveal that the ligand would be doubly deprotonated and that the Co(II) ion environment is a distorted octahedral one. (1) showed antibacterial activity similar to the ligand.

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“…Some of the synthesized compounds (11,18,21, and 28), especially 11 (SI = 90.83), showed good immunosuppressive activity but much lower than that elicited by CsA (SI = 235.44). The most active compound, 11, (SI = 90.83) had a pyrocatechol and bromine group, and could be a promising lead for the further development of novel therapeutic agents.…”

Section: Resultsmentioning

confidence: 95%

“…[18] Among the deoxybenzoins in previous reports, many compounds with the oxime group displayed potent biological activities and low toxicity, [19] some of them have been used as clinical medical agents and some kinds of oximes were reported to show immunosuppressive properties. [20] Schiff bases also exhibited antibacterial, [21] antifungal, [22] and antitumor activity. [23] Based on the previous reports, we focused our interest on new synthetic deoxybenzoins derivatives with an oxime group and Schiff base to explore new immunosuppressive agents with high efficacy and low toxicity.…”

Section: Introductionmentioning

confidence: 99%

Design, Synthesis, and Immunosuppressive Activity of New Deoxybenzoin Derivatives

Luo

Song

et al. 2010

ChemMedChem

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In the search for potential immunosuppressive agents with high efficacy and low toxicity, a series of new deoxybenzoins were synthesized and evaluated for their cytotoxicity and immunosuppressive activity. Among the synthesized compounds, four deoxybenzoin oximes (compounds 31, 32, 37, and 38) exhibited lower cytotoxicity and higher inhibitory activity toward anti-CD3/anti-CD28 co-stimulated T-cell proliferation than other compounds. More significantly, compound 31 is >100-fold less cytotoxic than cyclosporine A (CsA) and is also more potent (31: SI>684.64, CsA: SI=235.44). The preliminary inhibition mechanism of compound 31 was also identified by flow cytometry, and this compound exerts immunosuppressive activity by inducing apoptosis in activated lymph node cells in a dose-dependent manner. In addition, the mechanism of apoptosis was detected by western blot analysis.

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Synthesis, spectroscopic characterization and antibacterial activity of new cobalt(II) complexes of unsymmetrical tetradentate (OSN2) Schiff base ligands

Cited by 80 publications

References 27 publications

Synthesized of Sporopollenin-Immobilized Schiff Bases and Their Vanadium(IV) Sorption Studies

Synthesized of Sporopollenin-Immobilized Schiff Bases and Their Vanadium(IV) Sorption Studies

Synthesis, characterization and antimicrobial properties of a Co(II)-phthalylsulfathiazolate complex

Design, Synthesis, and Immunosuppressive Activity of New Deoxybenzoin Derivatives

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