Synthesis, spectroscopic characterisation, thermal analysis, DNA interaction and antibacterial activity of copper(I) complexes with N, N′- disubstituted thiourea

Abstract

copper(I) complexes [Cu(4MTU) 2 Cl] (2), [Cu(4MTU) (B)Cl] (3), [Cu(6MTU) 2 Cl] (5) and [Cu(6MTU) (B)Cl] ( 6) where 4MTU ¼ 1-Benzyl-3-(4-methyl-pyridin-2-yl)-thiourea (1) and 6MTU ¼ 1-Benzyl-3-(6-methylpyridin-2-yl)-thiourea (4), B is a N,N-donor heterocyclic base, viz. 1,10-phenanthroline (phen 3, 6), were synthesized, characterized by various physico-chemical and spectroscopic techniques. The elemental analysis suggests that the stoichiometry to be 1:2 (metal:ligand) for 2, 5 1:1:1 (metal:ligand:B) for 3, 6. Xray powder diffraction illustrates that the complexes have crystalline nature. IR data coupled with electronic spectra and molar conductance values suggest that the complex 2, 5 show the presence of a trigonal planar geometry and the complex 3, 6 show the presence of a tetrahedral geometry about the Cu(I) centre. The binding affinity towards calf thymus (CT) DNA was determined using UV-Vis, fluorescence spectroscopic titrations and viscosity studies. These studies showed that the tested phen complexes 3, 6 bind moderately (in the order of 10 5 M À1 ) to CT DNA. The complex 2, 5 does not show any apparent binding to the DNA and hence poor cleavage efficiency. Complex 3, 6 shows efficient oxidative cleavage of plasmid DNA in the presence of H 2 O 2 involving hydroxyl radical species as evidenced from the control data showing inhibition of DNA cleavage in the presence of DMSO and KI. The in vitro antibacterial assay indicates that these complexes are good antimicrobial agents against various pathogens. Anti-bacterial activity is higher when thiourea coordinates to metal ion than the thiourea alone.

Study on Semiconductor Properties of Acetylide-Thiourea Fabricated onto Interdigitated Electrodes (Ides) Platform Towards Application In Gas Sensing Technology

“…Strong absorption band of ν(C=O) was assigned at 1669 cm -1 associated to the resonance effect of aromatic conjugation of benzoyl ring along with the existence of intramolecular hydrogen bonding with N-H moiety which have same arguments with previous reported literatures [29], [30]. Moreover, the presence of asymmetric and symmetric stretching vibrations of secondary thioamide ν(N-H) is located at 3379 cm -1 [31], which examined to be above 3000 cm -1 due to the occurrence of intramolecular hydrogen bonding between carbonyl ν(C=O) and thiol ν(C=S) group. In addition, the overlapping band of ν(C≡C) and ν(C≡N) stretching vibration in TCN was observed at 2216 cm -1 with medium intensity.…”

Bis(thiosemicarbazone)copper(I) Complexes as Prospective Therapeutic Agents: Interaction with DNA/BSA Molecules, and In Vitro and In Vivo Anti‐Proliferative Activities

“…In the electronic spectra, all the complexes displayed an intense absorption band at 230 − 235 nm due to ligand based π–π* transition, while medium intense absorption band observed at 343–352 nm is due to intra‐ligand charge transfer transition, and because of d 10 electronic configuration of copper(I) complexes no bands appear above 400 nm. This study proves that the complexes contain copper in the +1 oxidation state …”

“…In this regard, the stability of copper(I) complexes in buffer solution was measured over various time intervals during 24, 48 and 72 h utilizing a kinetic program on a UV‐Vis spectroscopy ( Figure S14 ). The UV‐Vis spectra was recorded directly after dilution of the complexes did not show any differences after 24 and 48 h, while the 72 h samples show negligible differences, which authenticate the stability of the complexes in buffer solution, as also evidenced from ESI‐MS data.…”

Copper(II) Schiff base complexes and their mixed thin layers with ZnO nanoparticles

“…[1][2][3][4][5] These compounds are also known for their biological role and fluorescence properties. For instance, the copper(II) complexes with Schiff bases derived from trans (±)cyclohexanediamine and 2-pyridinecarboxaldehyde exhibited luminescence properties in the solution and in the solid state.…”

“…For example, [Cu 3 (opba)(pmdta) 2 ] (NO 3 ) 2 (pmdta = 1,1,4,7,7-pentamethyl-diethylenetriamine, opba = orthophenylenebis(oxamato)) complex was used to get thin layer of Cu(II) complex on SiO 2 /Si. 10 This technique was also used for deposition of [(nBu 3 P) 3 Cu-O 2 CCH 2 CO 2 -Cu(PnBu 3 ) 3 ] and [(nBu 3 P) 3 Cu-O 2 C(CH 2 ) 2 CO 2 -Cu(PnBu 3 ) 3 ] on SiO 2 / TiN/Cu substrate. The layers were then heated up to 450 • C, and the result of this process was the conversion of complexes to CuO by decomposition.…”