Synthesis, spectroscopic characterisation, electron microscopic study and thermogravimetric analysis of a phosphorus-containing dendrimer with phloroglucinol as a core unit

Abstract

A phosphorus-containing dendrimer of up to four generations with phloroglucinol as a core unit was synthesised using a divergent growth method. A repetitive synthetic sequence of several types of reactions was performed by using P(O)Cl 3 , 3-hydroxybenzaldehyde, 4-hydroxybenzaldehyde and p-phenylenediamine for the synthesis of this dendritic molecule G 4 involving simple condensation reactions. This Schiff's base macromolecule possesses 12 imine bonds and 6-OH groups on the periphery. The structures of the intermediate generations G 1 , G 2 , G 3 were confirmed by IR, 1 H, 13 C, 31 P NMR and LC/EI MS. The final dendrimer G 4 was characterised by IR, 1 H, 13 C, 31 P NMR, Maldi-tof mass spectrometer and C, H, N analysis. The scanning electronic microscopic study and thermogravimetric analysis were also performed for the final dendrimer (G 4 ).

Trigonal scaffolds for multivalent targeting of melanocortin receptors

“…To confirm this observation, we elected to pursue multivalent molecules based on the "disc-like" cores afforded by phloroglucinol (7), tripropargylamine (8), and 1,4,7-triazacyclononane (9). These compounds have been used as cores for dendrimeric molecules [34][35][36][37] and in syntheses of multivalent molecules. [38][39][40] Their simplicity and commercial availability suggest synthetic versatility and economy, important considerations for Organic & Biomolecular Chemistry Paper implementation of a general strategy for ligand multimerization.…”