Synthesis, spectroscopic, antimicrobial and DNA cleavage studies of new Co(II), Ni(II), Cu(II), Cd(II), Zn(II) and Hg(II) complexes with naphthofuran-2-carbohydrazide Schiff base

Halli, M. B.; Sumathi, R. B.

doi:10.1016/j.molstruc.2012.05.003

Cited by 55 publications

(11 citation statements)

References 18 publications

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“…The results indicated the important role of metal ions in isolated DNA cleavage reaction. Because the compounds were observed to DNA cleave activity, it can be concluded that, the compounds inhibit the several pathogenic organism growth by cleaving their genome . In addition to these, further investigations on anti‐cancer activity of the newly synthesized compounds should be studied.…”

Section: Resultsmentioning

confidence: 99%

Synthesis of Tetra 3,4‐dimethoxyphenethoxy Peripheral Substituted Metallophthalocyanines and Investigation of Some Properties

et al. 2018

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The synthesis and characterization of tetra 3,4-dimethoxyphenethoxy substituted cobalt, zinc and copper phthalocyanines are reported. These compounds have been characterized by using electronic absorption, nuclear magnetic resonance spectroscopy, infrared spectroscopy, and elemental analysis. The aggregation behaviors were investigated in different concentrations phthalocyanine complexes. The photodegradation stabilities of pthalocyanine complexes 4-6 were determined in THF. The antioxidant activities of scavenging effect on 1,1-Diphenyl-2-picryl-hydrazyl (DPPH) radicals and ferrous chelating reducing power were also investigated. The antimicrobial effects of compounds were evaluated. In addition, DNA cleavage activities of the ligand and its phthalocyanine complexes were experimented on plasmid DNA (pBR322) using DNA gel electrophoresis and the complexes exhibited promising cleavage activity. Thermal properties of compounds were determined by thermogravimetric analysis(TG) and differential thermal analysis (DTA).[a] Prof.

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Section: Resultsmentioning

confidence: 99%

Synthesis of Tetra 3,4‐dimethoxyphenethoxy Peripheral Substituted Metallophthalocyanines and Investigation of Some Properties

et al. 2018

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“…All chemicals used were of analytical reagent grade, and the solvents were distilled before use. Naphthofuran-2-carbohydrazide was synthesized according to the literature procedure [ 21 ]. The metal and chloride contents were determined as per Vogel's procedure [ 22 ].…”

Section: Methodsmentioning

confidence: 99%

Metal (II) Complexes Derived from Naphthofuran-2-carbohydrazide and Diacetylmonoxime Schiff Base: Synthesis, Spectroscopic, Electrochemical, and Biological Investigation

Sumathi

Halli

2014

Bioinorganic Chemistry and Applications

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A new Schiff base and a new series of Co(II), Ni(II), Cu(II), Cd(II), and Hg(II) complexes were synthesized by the condensation of naphthofuran-2-carbohydrazide and diacetylmonoxime. Metal complexes of the Schiff base were prepared from their chloride salts of Co(II), Ni(II), Cu(II), Cd(II), and Hg(II) in ethanol. The ligand along with its metal complexes have been characterized on the basis of analytical data, IR, electronic, mass, 1HNMR, ESR spectral data, thermal studies, magnetic susceptibility, and molar conductance measurements. The nonelectrolytic behaviour of the complexes was assessed from the measured low conductance data. The elemental analysis of the complexes confirm the stoichiometry of the type CuL2Cl2 and MLCl2 where M = Ni(II), Co(II), Cd(II), and Hg(II) and L = Schiff base. The redox property of the Cu(II) complex was investigated by electrochemical method using cyclic voltammetry. In the light of these results, Co(II), Ni(II), and Cu(II) complexes are assigned octahedral geometry, Cd(II), and Hg(II) complexes tetrahedral geometry. In order to evaluate the effect of metal ions upon chelation, both the ligand and its metal complexes were screened for their antibacterial and antifungal activities by minimum inhibitory concentration (MIC) method. The DNA cleaving capacity of all the complexes was analysed by agarose gel electrophoresis method.

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“…In the field of bioinorganic chemistry, the abilities of transition‐metal complexes, particularly biological activities, are fascinating . In particular, Schiff bases have attracted the attention of many researchers as they possess the ability to coordinate with metal complexes leading to a wide range of applications such as organic synthesis, catalysis, drug design, models for active sites of metalloenzymes, optoelectronic devices, and sensors, along with the biological activities . The Schiff base mixed ligand–metal complexes consist of an auxiliary ligand that may further promote the efficacy of the complex.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Spectral Characterization, Antitumor, Antioxidant, and Antimicrobial Studies of New Potential ONS Schiff Base Complexes

Alturiqi

Alaghaz

Ammar

2017

J Chinese Chemical Soc

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Novel Co(II), Ni(II), Cu(II), and Zn(II) complexes derived from 2‐aminopyridine‐3‐thiol and 4‐oxo‐4H‐chromene‐3‐carbaldehyde were synthesized and characterized by spectroscopic (IR, 1H NMR, UV–vis, ESR, and MS) and other analytical methods. Molar conductance data and magnetic susceptibility measurements provide evidence for the monomeric and monobasic nature of the complexes. The molar conductance measurement of the complexes in DMSO corresponds to their non‐electrolytic nature. All the complexes are of high‐spin type. On the basis of the different spectral studies, the six‐coordinated geometry may be assigned for all the complexes. IR spectral studies indicate the binding sites of the ligand with the metal ion. The Schiff base acts as tridentate ligand coordinated through deprotonated thiolic (SH) sulfur, azomethine (─CH═N─) nitrogen, and carbonyl (−C═O) oxygen atoms. The ligand field parameters were calculated for Co(II) and Ni(II) complexes and their values were found to be in the range reported for an octahedral structure. The data show that the complexes have an ML2‐type composition. The activation thermodynamic parameters are calculated using the Coast–Redfern, Horowitz–Metzger (HM), Piloyan–Novikova (PN), and Broido equations. The X‐ray diffraction data suggest a triclinic system for all compounds. Different surface morphologies were identified from SEM micrographs. Human tumor cell lines A427 (lung cancer cell line), LCLC‐103H (large cell lung cancer), SISO (uterine adenocarcinoma), and 5637(human bladder carcinoma) grown in RPMI‐1640 medium were elevated. The biological screening data show that the complexes show growth inhibitory activity against various microorganisms. The octahedral geometry of the complexes is confirmed using density functional theory (DFT) from DMOL3 calculations, electronic and magnetic moment measurements, ESR, and ligand field parameters.

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Synthesis, spectroscopic, antimicrobial and DNA cleavage studies of new Co(II), Ni(II), Cu(II), Cd(II), Zn(II) and Hg(II) complexes with naphthofuran-2-carbohydrazide Schiff base

Cited by 55 publications

References 18 publications

Synthesis of Tetra 3,4‐dimethoxyphenethoxy Peripheral Substituted Metallophthalocyanines and Investigation of Some Properties

Synthesis of Tetra 3,4‐dimethoxyphenethoxy Peripheral Substituted Metallophthalocyanines and Investigation of Some Properties

Metal (II) Complexes Derived from Naphthofuran-2-carbohydrazide and Diacetylmonoxime Schiff Base: Synthesis, Spectroscopic, Electrochemical, and Biological Investigation

Synthesis, Spectral Characterization, Antitumor, Antioxidant, and Antimicrobial Studies of New Potential ONS Schiff Base Complexes

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