Synthesis, spectroscopic and crystal structure of nickel(II) complex of thiosemicarbazone basedSchiff base: Antimicrobial, anticancer and molecular docking studies

Theoretical, in Vitro Antiproliferative, and in Silico Molecular Docking and Pharmacokinetics Studies of Heteroleptic Nickel(II) and Copper(II) Complexes of Thiosemicarbazone‐Based Ligands and Pefloxacin

“…Further, the nickel(II) complexes (1)(2)(3)(4)(5)(6) showed three weak absorption bands in the visible region at 728-749, 835-843 and 936-960 nm due to 3 A 2g ! 3 T 2g (F), 3 A 2g ! 3 T 1g (F) and 3 A 2g !…”

“…The pefloxacin drug exhibits two significant absorption bands at 1632 and 1308 cm À 1 due to υ(COO) asym and υ(COO) sym vibrations, respec-Scheme 1. Synthesis of heteroleptic nickel(II) and copper(II) complexes (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12).…”

“…The information about the geometric structure and electronic transitions of the synthesized heteroleptic metal(II) complexes (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12) were revealed by recording the electronic spectra in DMF solution in the wavelength range of 200-1000 nm (Figures S7 and S8). All the metal complexes showed a high intensity absorption band at 272-289 nm and a medium intensity band at 318-342 nm, which are assigned to an intraligand charge transfer transition (π!π*) and charge transfer from the oxygen atom of the pefloxacin moiety to the metal ion (n!π*), respectively.…”

“…In vitro antiproliferative activity (IC 50 values) of the heteroleptic metal(II) complexes(1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12) and cisplatin drug against breast cancerous (T47D, MDA-MB-231 and MCF-7) and non-tumorigenic human breast epithelial (MCF-10a) cell lines.…”

A 3D hierarchical porous adsorbent constructed by cryo-polymerization for ultrafast uranium harvesting from seawater

“…[11][12][13][14] In order to improve the antibacterial ability of adsorbents, the construction of a salicylaldehyde Schiff base group is an effective method due to its cellular penetration capacity to damage bacterial cells. 15,16 Meanwhile, Schiff base groups also tend to coordinate with uranyl and other heavy metal ions. 17,18 Although the above functional groups may address issues like uranium uptake capacity, selectivity and antibacterial properties, it is still challenging to achieve their cooperative anchoring on the adsorbents, especially for obtaining a mechanically stable structure with large ux and high capacity.…”