Synthesis, spectral, thermal, fluorescence, antimicrobial, anthelmintic and DNA cleavage studies of mononuclear metal chelates of bi-dentate 2H-chromene-2-one Schiff base

Prabhakara, Chetan T.; Patil, Sangamesh A.; Kulkarni, Ajaykumar D.; Naik, Vinod H.; Manjunatha, M.; Kinnal, Shivshankar M.; Badami, Prema S.

doi:10.1016/j.jphotobiol.2015.03.033

Cited by 25 publications

(9 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Schiff bases are useful ligands and important organic fragments. The azomethine (C=N) functional group is a versatile pharmacophore for the design of bioactive compounds with a broad range of effects, including anti-inflammatory, 1,2) antibacterial, 3,4) antifungal, 3) analgesic, 2,5) antimicrobial, 3,6,7) anticonvulsant, 5) antitubercular, anticancer, 5,8) antioxidant, 9) anthelmintic, 10) antiglycation 11) and antidepressant. 12) Schiff bases are extensively employed as chelating ligands in the field of coordination chemistry.…”

mentioning

confidence: 99%

“…Among Schiff bases, the organotin(IV) complexes containing Nitrogen Sulfur (NS), Nitrogen Oxygen (NO), Oxygen Nitrgen Oxygen (ONO) and Oxygen Nitrogen Sulfur (ONS) donor atoms have shown great appeal due to their structural features, which can provide antimicrobial, antifungal, antibacterial, antioxidant and carcinostatic activity. 9,[13][14][15][16] The amino acids and their derivatives have been the subject of intense research efforts because of their coordination properties and potential for generating effective and less toxic metalbased drugs. Additionally, their physico-chemical properties and specific mechanism of transport facilitate facile biological uptake.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Dibutyltin(IV) Complexes Derived from L-DOPA: Synthesis, Molecular Docking, Cytotoxic and Antifungal Activity

Castillo

Gómez-García

Andrade-Pavón

et al. 2018

CHEMICAL & PHARMACEUTICAL BULLETIN

View full text Add to dashboard Cite

A series of organotin(IV) complexes was herein prepared and characterized. A one-pot synthetic strategy afforded reasonable to high yields, depending on the nature of the ligand. All new complexes were fully characterized by spectroscopic techniques, consisting of IR, MS and NMR (1 H, 13 C and 119 Sn). The in vitro cytotoxicity tests demonstrated that the organotin complexes produced a greater inhibition, versus cisplatin (the positive control), of the growth of six human cancer cell lines: U-251 (glioblastoma), K-562 (chronic myelogenous leukemia), HCT-15 (colorectal), MCF-7 (breast), MDA-MB-231 (breast) and SKLU-1 (non-small cell lung). The potency of this cytotoxic activity depended on the nature of the substituent bonded to the aromatic ring. All complexes exhibited excellent IC 50 values. The test compounds were also screened in vitro for their antifungal effect against Candida glabrata and Candida albicans, showing minimum inhibitory concentration (MIC) values lower than those obtained for fluconazole. A brine shrimp bioassay was performed to examine the toxic properties. Molecular docking studies demonstrated that the organotin(IV) complexes bind at the active site of topoisomerase I in a similar manner to topotecan, sharing affinity for certain amino acid side chains (Ile535, Arg364 and Asp533), as well as for similar DNA regions (DA113, DC112 and DT10).

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

Dibutyltin(IV) Complexes Derived from L-DOPA: Synthesis, Molecular Docking, Cytotoxic and Antifungal Activity

Castillo

Gómez-García

Andrade-Pavón

et al. 2018

CHEMICAL & PHARMACEUTICAL BULLETIN

View full text Add to dashboard Cite

show abstract

“…Designing small molecules help in targeting specific sites on a DNA strand and can lead to novel therapeutic agents. Photocleavage study of DNA also helps in various applications like photodynamic therapy of cancers, DNA foot printing agents and in genomic research [42,43].…”

Section: Dna Cleavage Studiesmentioning

confidence: 99%

Anticancer activity studies of novel metal complexes of ligands derived from polycyclic aromatic compound via greener route

Kumbar

Patil

Toragalmath³

et al. 2020

Journal of Organometallic Chemistry

Self Cite

View full text Add to dashboard Cite

“…This also suggests that the unpaired electron exists in d x , i.e., G = 3.28 < 4.0. Here, g 11 < 2.3 explains the covalent nature of the M→L bonding [35]. The covalency parameter α 2 (= 0.44) is also calculated by using the following expression, which also suggests the covalent nature of the copper complexes.…”

Section: Esr Spectramentioning

confidence: 99%

Synthesis, spectral, thermal, kinetic and antibacterial studies of transition metal complexes with benzimidazolyl-2-hydrazones of o-hydroxyacetophenone, o-hydroxybenzophenone and o-vanillin

Mohapatra¹,

Das²,

El-ajaily³

et al. 2018

Bull. Chem. Soc. Eth.

View full text Add to dashboard Cite

A novel series of Schiff base metal complexes of the type [M(L)2].nH2O, where L= 2-(αmethylsalicylidenehydrazino) benzimidazole (L1), 2-(α-phenylsalicylidenehydrazino)benzimidazole (L2), 2-(o-vanillinidenehydrazino)benzimidazole (L3), M = Cu(II), Co(II), Ni(II) and Zn(II), have been synthesized and characterized. The results are in consistent with tridentate chelation of ligand with azomethine nitrogen, ring nitrogen and a deprotonated phenolic oxygen atom. All these compounds have been screened for their antibacterial activities against B. subtilis, B. stearothermophilus, E. coli and S. typhi.

show abstract

Synthesis, spectral, thermal, fluorescence, antimicrobial, anthelmintic and DNA cleavage studies of mononuclear metal chelates of bi-dentate 2H-chromene-2-one Schiff base

Cited by 25 publications

References 36 publications

Dibutyltin(IV) Complexes Derived from L-DOPA: Synthesis, Molecular Docking, Cytotoxic and Antifungal Activity

Dibutyltin(IV) Complexes Derived from L-DOPA: Synthesis, Molecular Docking, Cytotoxic and Antifungal Activity

Anticancer activity studies of novel metal complexes of ligands derived from polycyclic aromatic compound via greener route

Synthesis, spectral, thermal, kinetic and antibacterial studies of transition metal complexes with benzimidazolyl-2-hydrazones of o-hydroxyacetophenone, o-hydroxybenzophenone and o-vanillin

Contact Info

Product

Resources

About