Synthesis, spectral studies, in vitro antimicrobial activity and molecular docking studies of organotin(IV) complexes derived from tridentate Schiff base ligands

Saroya, Sonia; Asija, Sonika; Deswal, Yogesh; Kumar, Naresh; Kumar, Ashwani

doi:10.1007/s11164-022-04731-8

Cited by 14 publications

(5 citation statements)

References 66 publications

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“…The obtained mass spectral results substantiate the complexation of ligand with the metal ions in a molar ratio of 1:1, as also suggested by other spectral findings. [ 62 ]…”

Section: Resultsmentioning

confidence: 99%

“…The nickel complex showed absorption bands at 25132 cm −1 and 13,998 cm −1 , which were ascribed to 3 A 2g (F) → 3 T 1g (P) and 3 A 2g (F) → 3 T 1g (F) transitions respectively, thereby further revealing the octahedral geometry around the nickel complex. [ 62 ] The spectrum of copper complex displayed a band at 19119 cm −1 , which was assigned to the 2 B 1g → 2 A 1g transition. Absence of a band below 16,000 cm −1 rules out the possibility of tetrahedral geometry in copper complex.…”

Section: Resultsmentioning

confidence: 99%

“…3 T 1g (F) transitions respectively, thereby further revealing the octahedral geometry around the nickel complex. [62] The spectrum of copper complex displayed a band at 19119 cm À1 , which was assigned to the 2 B 1g ! 2 A 1g transition.…”

Section: Electronic Spectramentioning

confidence: 99%

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Instigating the in vitro antidiabetic activity of new tridentate Schiff base ligand appended M(II) complexes: From synthesis, structural characterization, quantum computational calculations to molecular docking, and molecular dynamics simulation studies

Deswal

Asija

Tufail³

et al. 2023

Applied Organom Chemis

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In search of novel medications that could be effective in preventing and treating diabetes, four new [Co(L)(H 2 O) 3 ] (2), [Ni(L)(H 2 O) 3 ] (3), [Cu(L)(H 2 O)] (4) and [Zn(L)(H 2 O)] (5) complexes were synthesized from 4-Chloro-2-(((3-mercapto-5-[pyridin-4-yl]-4H-1,2,4-triazol-4-yl)imino)methyl)phenol ligand (H 2 L),which is obtained by the condensation of 5-chlorosalicylaldehyde with 4-amino-5-(pyridin-4-yl)-4H-1,2,4-triazole-3-thiol in 1:1 ratio. The Fouriertransform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR)( 1 H and 13 C), elemental analyses, UV-visible, electron spin resonance (ESR), thermogravimetric analysis (TGA), scanning electron microscopy, energy dispersive X-ray analysis (EDAX), and X-ray diffraction (XRD) studies were used to successfully characterize the compounds. The ligand act in a tridentate manner and coordinates to the metal ions through N azomethine , O phenolic and S thiol functionalities. On the premise of their spectral and physico-analytical data; octahedral geometry for complex 2 and 3, while square planar and tetrahedral geometry for complex 4 and 5 was proposed. Theoretical calculations of the synthesized compounds have been performed by using density functional theory (DFT)/B3LYP method and parameters such as HOMO-LUMO energy values and MESP were calculated. In vitro examinations against α-amylase and α-glucosidase reveal promising results for the compounds. Nickel (II) complex(3) against α-amylase and zinc (II) complex (5) against α-glucosidase were found to be good inhibitors. Molecular docking experiments against the receptors 1BSI and 5ZCC were done to support the observation and considerable

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“…The obtained mass spectral results substantiate the complexation of ligand with the metal ions in a molar ratio of 1:1, as also suggested by other spectral findings. [ 62 ]…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Instigating the in vitro antidiabetic activity of new tridentate Schiff base ligand appended M(II) complexes: From synthesis, structural characterization, quantum computational calculations to molecular docking, and molecular dynamics simulation studies

Deswal

Asija

Tufail³

et al. 2023

Applied Organom Chemis

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“…By comparing the activity of ligands ( 1–3 ), it was established that H 2 L 1 (MIC = 0.0656–0.0328 µmol/mL) was more active as compared to other ligands. The greater activity of H 2 L 1 ligand was due to the companionship of electron-withdrawing nitro group present on the salicylaldehydic ring, while H 2 L 3 (MIC = 0.0714–0.0357 µmol/mL) was least active due to the presence of electron-donating methyl group [ 54 ]. The ligand H 2 L 2 (MIC = 0.0684–0.0342 µmol/mL) having –OCH 3 group attached to the salicylaldehyde ring was found to show moderate inhibition.…”

Section: Resultsmentioning

confidence: 99%

Development of new tridentate ligands bearing hydrazone motif and their diorganotin(IV) complexes: Synthesis, spectral, antimicrobial and molecular docking studies

et al. 2022

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Current antimicrobial drug discovery and advancement attempts are aimed to identify new complexes that can work effectively against the infections caused by microbes. The aim of present study was to synthesize new diorganotin(IV) complexes of N' -((8-hydroxy-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-9-yl)methylene)-2-nitrobenzohydrazide (H 2 L 1 ), N' -((8-hydroxy-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-9-yl)methylene)-3-methoxybenzohydrazide (H 2 L 2 ) and N' -((8-hydroxy-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-9-yl)methylene)-4-methylbenzohydrazide (H 2 L 3 ) Schiff base ligands with formula R 2 SnL 1−3 (where R = Me, Et, Bu and Ph). Various spectral and physico-analytical techniques such as elemental analysis, FT-IR, multinuclear ( 1 H, 13 C, 119 Sn) NMR, HRMS and XRD were utilized to structurally elucidate the prepared compounds. Based on the spectral data, it was concluded that ligands behave in a tridentate manner and coordinates to the central tin atom through ONO donor atoms. Furthermore, the synthesized compounds were examined for in vitro antimicrobial activity against four bacterial and two fungal strains. Among the examined compounds, Ph 2 SnL 1 complex (MIC = 0.0095 µmol/mL) was found to be the most active. To rationalize the preferred mode of interactions of the most active compound, a molecular docking study of compound Ph 2 SnL 1 was executed in the binding site of 3-oxoacyl-[acyl-carrier-protein] synthase 2 (FabF) of E. coli and sterol 14-alpha demethylase of C. albicans . Compound Ph 2 SnL 1 inhibits the microbes effectively and it could be an effective and new candidate for the modulation of various infections. Graphical Abstract New diorganotin(IV) complexes ( 4–15 ) were prepared from tridentate Schiff base hydrazones ( 1–3 ). The compounds were examined for in vitro antimicrobial activity. Further, molecular docking study of the most potent compound Ph 2 SnL 1 ( 7 ) was performed against the enzyme 3-oxoacyl-[acyl-carrier-protein] synthase 2 (FabF) of E. coli and sterol 14-alpha demethylase of C. albicans . Supplementary Information The online version contains supplementary material avail...

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“…In this field, several important research dedicated to Kumar et al have demonstrated that some compounds containing transition metals and Schiff base ligands possess significant antidiabetic properties. [3][4][5] In this context, N,O-donors ligands such as 1,2,4-triazole and carboxylate derivatives are the subject of several studies due to their interesting activities in biological and pharmacological field. [6,7] Biologically, they have a wide range of activities such as antimicrobials, bactericides, fungicides, antidiabetic, and antitumor.…”

Section: Introductionmentioning

confidence: 99%

Crystal Structure, Magnetic Study, and Antidiabetic Activity of Ni(II) Complex with N,O‐Donors Ligands

Selmi

Saïd

Nasri

et al. 2022

Cryst. Res. Technol.

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Coordination chemistry of divalent ions involving multidentate ligands have received limited attention. The present work reports the synthesis of a mixed ligand complex of Ni(II) which is characterized by X-ray single-crystal diffraction, thermal, IR spectroscopy, magnetic, and in vitro antidiabetic activity. The atomic arrangement of the complex consists of two Ni(II) bridged by two ligands of organic molecules 5-(pyridin-2-yl)-1,2,4-triazol-1-ide (Ligand L1) and 2-(4-chlorobenzoyl)benzoate (Ligand L2) which throw their nitrogen and oxygen atoms. The Ni 2+ adopts a distorted octahedral geometry (NiO 2 N 2 (OH 2 ) 2 ). Infrared spectroscopy shows the existence of O─H, C─N, C═O, and absorption bands Ni─ (O,N). The thermal study proves that this compound undergoes dehydration then decomposition over a large domain of temperature. The magnetic properties of the complex demonstrate an antiferromagnetic interaction between two adjacent nickel atoms mediated by throw ligand (L1). The antidiabetic effect of this compound is supported by a biological test in vitro and is confirmed by molecular docking suggesting good inhibitory activity of the prepared complex for 𝜶-amylase.

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Synthesis, spectral studies, in vitro antimicrobial activity and molecular docking studies of organotin(IV) complexes derived from tridentate Schiff base ligands

Cited by 14 publications

References 66 publications

Instigating the in vitro antidiabetic activity of new tridentate Schiff base ligand appended M(II) complexes: From synthesis, structural characterization, quantum computational calculations to molecular docking, and molecular dynamics simulation studies

Instigating the in vitro antidiabetic activity of new tridentate Schiff base ligand appended M(II) complexes: From synthesis, structural characterization, quantum computational calculations to molecular docking, and molecular dynamics simulation studies

Development of new tridentate ligands bearing hydrazone motif and their diorganotin(IV) complexes: Synthesis, spectral, antimicrobial and molecular docking studies

Crystal Structure, Magnetic Study, and Antidiabetic Activity of Ni(II) Complex with N,O‐Donors Ligands

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