Synthesis, spectral, crystal structure and in vitro antimicrobial evaluation of imidazole/benzotriazole substituted piperidin-4-one derivatives

Design, synthesis and evaluation of benzotriazole derivatives as novel antifungal agents

“…3,4 The emergence of resistance spells the need to discover new antifungal compounds with a broad antifungal spectrum and with higher therapeutic indices than existing antifungal agents. Khabnadideh et al, 5 Nitin et al, 6 and Ramachandran et al 7 have published approaches for design and synthesis of 1-substituted benzotriazole derivatives with promising antifungal activity and targeting enzyme lanosterol 14a-demethylase. We have designed 160 benzotriazole derivatives substituted at 1, 4 or 5 position as antifungal agents.…”

2-(chromon-3-yl)imidazole derivatives as potential antimicrobial agents: synthesis, biological evaluation and molecular docking studies

“…According to literature reports, clinically used azoles such as clotrimazole, miconazole and econazole containing imidazole nucleus exhibit significant antimicrobial spectrum though inhibition of enzyme lanosterol 14α-demethylase [12]. Various imidazole-based lead compounds such as 3-aryl-4-(4,5-diphenyl-1H-imidazol-2-yl)-1H-pyrazole [13], N-(4-aryl-1H-imidazol-2-yl)cinnamamide [14] and substituted 1-[2-(1H-imidazol-1-yl)acetyl]-2,6-diarylpiperidin-4-one [15] have also been screened for in vitro antibacterial and antifungal activities against various pathogenic microbial strains and displayed promising inhibitory potential.…”

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“…Among the compounds, fluoro and methoxy group substituted compound 6d ( Fig. 7) showed good antimicrobial activity at minimum concentration 11 .…”