Synthesis, spectral characterization, molecular structure and pharmacological studies of N’-(1, 4-naphtho-quinone-2yl) isonicotinohyWdrazide

Rani, P.R. Kavitha; Fernandez, Annette; George, Annie; Remadevi, V.K.; Sudarsanakumar, M.R.; Laila, Shiny P.; Arif, M

doi:10.1016/j.saa.2014.07.092

Cited by 18 publications

(7 citation statements)

References 14 publications

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“…Cytotoxicity experiments were performed using the MTT test on human breast adenocarcinoma (MCF-7) and colon cancer (HCT-15) cell lines to assess NIH's potential as a therapeutic agent. 53 Scheme 25 N'-(1,4-naphtho-quinone-2-yl) isonicotinohydrazide (NIH) derivative 79.…”

Section: Benzo[a]pyridazino[34-c] Phenazine Derivativesmentioning

confidence: 99%

Recent Advances in the Synthesis of 2-Hydroxy-1,4-naphthoquinone (Lawsone) Derivatives

Sagar,

Shankar,

Khanna

et al. 2023

SynOpen

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Lawsone, also known as 2-hydroxy-1,4-naphthoquinone, has been extensively studied and found to be a crucial precursor in the production of a diverse range of natural products like molecular scaffolds, which are highly sought after for biological research purposes. Due to its unique chemical composition, Lawsone has been utilized for over a century as a starting material for the synthesis of numerous biologically active molecules and materials, showcasing intriguing properties across a wide range of scientific and technological applications. Additionally, Lawsone has been widely used in organic synthesis processes, with its various applications. The recent advances in the synthesis of different scaffolds starting from Lawsone and their applications are being discussed in details in the current review covering the literature during the period of 2017-2023.

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Section: Benzo[a]pyridazino[34-c] Phenazine Derivativesmentioning

confidence: 99%

Recent Advances in the Synthesis of 2-Hydroxy-1,4-naphthoquinone (Lawsone) Derivatives

Sagar,

Shankar,

Khanna

et al. 2023

SynOpen

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“…This phenolic quinone compound has been evaluated to possess a wide range of biological and pharmacological activities such as antioxidant, antibacterial, antifungal, cytotoxic, trypsin inhibitor, anticoagulant, advanced glycation end products (AGEs) formation inhibitor, and anti‐acute pancreatitis . The interesting structural pattern of lawsone coupled with its so‐called multifaceted pharmacological potential has motivated chemists to explore this useful scaffold in certain chemical processes, particularly in synthesizing ligands for metal complexation, and a few of its derivatives have already been reported to exhibit a number of biological activities …”

Section: Designing Organic Transformations At Ambient Conditionsmentioning

confidence: 99%

Design of Organic Transformations at Ambient Conditions: Our Sincere Efforts to the Cause of Green Chemistry Practice

Brahmachari

2015

The Chemical Record

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This account summarizes our recent efforts in designing a good number of important organic transformations leading to the synthesis of biologically relevant compounds at room temperature and pressure. Currently, the concept of green chemistry is globally acclaimed and has already advanced quite significantly to emerge as a distinct branch of chemical sciences. Among the principles of green chemistry, one principle is dedicated to the "design of energy efficiency" - that is, to develop synthetic strategies that require less or the minimum amount of energy to carry out a specific reaction with optimum productivity - and the most effective way to save energy is to develop strategies/protocols that are capable enough to carry out the transformations at ambient temperature! As part of on-going developments in green synthetic strategies, the design of reactions under ambient conditions coupled with other green aspects is, thus, an area of current interest. The concept of developing reaction strategies at room temperature and pressure is now an emerging field of research in organic chemistry and is progressing steadily. This account is aimed to offer an overview of our recent research works directly related to this particular field of interest, and highlights the green chemistry practice leading to carbon-carbon and carbon-heteroatom bond-forming reactions of topical significance. Green synthetic routes to a variety of biologically relevant organic molecules (heterocyclic, heteroaromatic, alicyclic, acyclic, etc.) at room temperature and pressure are discussed.

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“…Lawsone has been evaluated to possess a wide range of biological and pharmacological activities such as antioxidant, antibacterial, antifungal, cytotoxic, trypsin inhibitor, anticoagulant, advanced glycated end products (AGEs) formation inhibitor, antiacute pancreatitis and many more . The interesting structural pattern of lawsone coupled with its so-called multifaceted pharmacological potential have motivated the chemists to explore this useful scaffold in certain chemical processes, particularly in synthesizing ligands for metal complexations , and also few of its derivatives having a number of biological activities , as reported so far.…”

Section: Introductionmentioning

confidence: 99%

“…Lawsone has been evaluated to possess a wide range of biological and pharmacological activities such as antioxidant, 25 antibacterial, 26 antifungal, 27 cytotoxic, 28 trypsin inhibitor, 29 anticoagulant, 30 advanced glycated end products (AGEs) formation inhibitor, 31 antiacute pancreatitis 32 and many more. 24 The interesting structural pattern of lawsone coupled with its so-called multifaceted pharmacological potential have motivated the chemists to explore this useful scaffold in certain chemical processes, particularly in synthesizing ligands for metal complexations 33,34 and also few of its derivatives having a number of biological activities 35,36 as reported so far. However, available reports on the novel scaffold developments with lawsone are still very limited, and hence a systematic effort has been taken to develop a simple, efficient and eco-friendly protocol for the synthesis of a series of 3,3′-(aryl/alkyl-methylene)bis(2-hydroxynaphthalene-1,4-dione) scaffolds from lawsone with a view that the synthetic bislawsone derivatives would exhibit certain promising biological activities, as these molecules bear the lawsone moiety as a substructure.…”

Section: ■ Introductionmentioning

confidence: 99%

“…24 The interesting structural pattern of lawsone coupled with its so-called multifaceted pharmacological potential have motivated the chemists to explore this useful scaffold in certain chemical processes, particularly in synthesizing ligands for metal complexations 33,34 and also few of its derivatives having a number of biological activities 35,36 as reported so far.…”

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Sulfamic Acid-Catalyzed One-Pot Room Temperature Synthesis of Biologically Relevant Bis-Lawsone Derivatives

Brahmachari

2015

ACS Sustainable Chem. Eng.

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________________________________________________________________________ ABSTRACTA simple and energy-efficient green protocol for the synthesis of a series of biologically interesting functionalized bis-lowsone [i.e. 3,3'-(aryl/alkyl-methylene)bis(2-hydroxynaphthalene-1,4-dione)] scaffolds has been developed in the presence of sulfamic acid as an eco-friendly organocatalyst via one-pot pseudo-multicomponent reaction at room temperature. The salient features of the present protocol are mild reaction conditions, good to excellent yields, operational simplicity, energy-efficiency, high atom-economy, ecofriendliness, easy isolation of products and no column chromatographic separation. ______________________________________________________________________________

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Synthesis, spectral characterization, molecular structure and pharmacological studies of N’-(1, 4-naphtho-quinone-2yl) isonicotinohyWdrazide

Cited by 18 publications

References 14 publications

Recent Advances in the Synthesis of 2-Hydroxy-1,4-naphthoquinone (Lawsone) Derivatives

Recent Advances in the Synthesis of 2-Hydroxy-1,4-naphthoquinone (Lawsone) Derivatives

Design of Organic Transformations at Ambient Conditions: Our Sincere Efforts to the Cause of Green Chemistry Practice

Sulfamic Acid-Catalyzed One-Pot Room Temperature Synthesis of Biologically Relevant Bis-Lawsone Derivatives

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