Synthesis, Spectral Characterization, Molecular Modeling, and Antimicrobial Studies of Cu(II), Ni(II), Co(II), Mn(II), and Zn(II) Complexes of ONO Schiff Base

Abstract

A series of Cu(II), Ni(II), Co(II), Mn(II), and Zn(II) complexes have been synthesized from the schiff base ligand L. The schiff base ligand [(4-oxo-4H-chromen-3-yl) methylene] benzohydrazide (L) has been synthesized by the reaction between chromone-3-carbaldehyde and benzoyl hydrazine. The nature of bonding and geometry of the transition metal complexes as well as schiff base ligand L have been deduced from elemental analysis, FT-IR, UV-Vis,1HNMR, ESR spectral studies, mass, thermal (TGA and DTA) analysis, magnetic susceptibility, and molar conductance measurements. Cu(II), Ni(II), Co(II), and Mn(II) metal ions are forming 1:2 (M:L) complexes, Zn(II) is forming 1:1 (M:L) complex. Based on elemental, conductance and spectral studies, six-coordinated geometry was assigned for Cu(II), Ni(II), Co(II), Mn(II), and Zn(II) complexes. The complexes are 1:2 electrolytes in DMSO except zinc complex, which is neutral in DMSO. The ligand L acts as tridentate and coordinates through nitrogen atom of azomethine group, oxygen atom of keto group ofγ-pyrone ring and oxygen atom of hydrazoic group of benzoyl hydrazine. The 3D molecular modeling and energies of all the compounds are furnished. The biological activity of the ligand and its complexes have been studied on the four bacteriaE. coli, Edwardella, Pseudomonas, andB. subtilisand two fungipencilliumandtricodermaby well disc and fusion method and found that the metal chelates are more active than the free schiff base ligand.

Synthesis, characterization and anticancer activity of 3-formylchromone benzoylhydrazone metal complexes

“…The IR spectrum of Hfcbh exhibits strong bands at 1,676 and 1,616 cm -1 , which are assigned to m(C=O) pyrone and azomethine m(C=N), respectively [29]. Upon complexation, these bands are shifted to lower wave numbers, indicating the involvement of the pyrone carbonyl oxygen and azomethine nitrogen atoms in coordination [1,29,30].…”

“…Upon complexation, these bands are shifted to lower wave numbers, indicating the involvement of the pyrone carbonyl oxygen and azomethine nitrogen atoms in coordination [1,29,30].…”

Synthesis of (E)-4-Methyl-2-((Phenethylimino (Phenyl)methyl)phenol and Its Transition Metal Complexes, Characterization and Electrical Conductivity Study of Complexes

“…36,37 38 These three bands are consistent with octahedral geometry. [39][40][41][42][43] The absorption bands of Cu(II) complex corresponds to square planar geometry. 44,45 The Zn(II) and Cd(II) complexes of HMBPE show no d-d transitions.…”

Synthesis, Thermal Characterization and in vitro Antibacterial Assessment of Co(II) and Cd(II) Complexes of Schiff Base Derived from Amoxicillin and Thiophene-2-carbaldehyde

“…The reasonable and low energy molecular geometries were obtained through manipulation and modification of the molecular coordinates. The energy optimization was repeated several times to find the minimum energy molecular geometry [36][37][38]. The bonding parameters such as bond length and bond angles data of AMXTC2 and its metal complexes, optimized by MM2 calculation are reported in Table-6 and their 3D molecular structures are presented in Figs.…”