Synthesis, Spectral Characterization, Antibacterial and Anticancer Evaluation of Novel Isoniazid based Schiff Base Ligand derived Transition Metal Complexes

Abstract

A novel isoniazid based Schiff base ligand was synthesized by the condensation of 5-acetyl-N-(adamantan-2-yl)thiophene-2-carboxamide (1 mmol) and isoniazid (1 mmol). Metal complexes were prepared by reacting the Schiff base with metal(II) chloride (M = Ni2+, Cu2+ and Co2+), formed the novel metal coordination compound. The synthesized ligand and metal complexes were characterized by 1H NMR, mass spectral, UV-visible, IR & EPR spectral studies, themogravimetric analysis, cyclic voltametry and were screened with both Gram-positive and Gram-negative bacterias to evaluate the antibacterial activity by disc diffusion method. The zone of inhibition of the antibacterial assay demonstrated that all the three metal(II) complexes are active against the four bacterias, showed increased activity with increase in concentration and is more active against S. aureas at all concentrations. The systhesized complexes were also evaluated for its anticancer activities, only Ni(II) and Co(II) complexes showed the moderate levels of cytotoxicity activity.