Synthesis, spectral characterization and biological evaluation of Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) complexes with thiosemicarbazone ending by pyrazole and pyridyl rings

Metal Complex Derivatives of Azole: a Study on Their Synthesis, Characterization, and Antibacterial and Antifungal Activities

“…The aliphatic asymmetric C−H vibration in free ligand (3) (3115 cm -1 ) appears to shift, and in complex (10), it was observed at 3120 cm -1 . 18,40 It was also possible to observe the shift and the decreased intensity of the band at 1494 cm -1 as assigned to the N−C and C=C of the pyridine ring in (5), which appear in (12) at 1500 cm -1 . 41,42 This shift indicates a moderate interaction between the metal center and the pyridinic nitrogen of the ligand (Scheme 2).…”

“…[16][17][18][19][20] The increased antimicrobial activity is likely related to azole's better solubility, bioavailability and interaction with DNA (deoxyribonucleic acid) through intermolecular associations. 19,20 Increased lipophilicity in the complexes reduces the permeability barrier of cells and slows normal cellular processes in microorganisms, resulting in increased antimicrobial activity.…”

“…In the case of (6) and (13), the band that assigned C=C to the aromatic toluene ring was found in both the ligands and complexes; it indicates that there was no Zn-toluene interaction. In addition to complexes (8)(9)(10)(11)(12)(13)(14), weak absorption bands in the 450-550 cm -1 ranges could be assigned to Zn−N vibration, 18,43 or Zn−Cl vibration if we consider the range described by Socrates. 42 …”

Ni(ii) complex with bishydrazone ligand: synthesis, characterization, DNA binding studies and pro-apoptotic and pro-differentiation induction in human cancerous cell lines

“…[12][13][14] Hydrazone complexes of Ni exhibit a wide spectrum of biological activity, 11 and a number of these complexes have shown higher anti-cancer activity than the drugs approved for treatment of certain types of cancer. [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] Ni(II) ion has d 8 electronic conguration, same as Pt(II)the metal ion in, so far, all of the approved anti-cancer treatment drugs: cisplatin (CDDP), carboplatin, oxaliplatin, nedaplatin, and lobaplatin. 30 Unlike Pt(II), which only exhibits square-planar geometry (coordination number four), Ni(II) oen exhibits higher coordination numbers, offering greater variation in geometry.…”

Structural, spectral, thermal and biological studies on (Z)-N-benzoyl-N′-(2-oxo-2-(phenylamino)acetyl)carbamohydrazonothioic acid (H2PABT) and its Cd(II), Hg(II), Zn(II) and U(VI)O22+ complexes

“…These gratifying results are encouraging its further screening in vitro. Therefore, its further biological evaluation in vivo as well as studies of mechanism of action is necessary [54]. …”