“…These derivatives can be prepared by cyclocondensation of 1-(2-aminoaryl) urea with diethyl malonate, 2-substituted benzimidazolylacetates with carbonate esters [1][2][3][4][5][6], condensation of ketoisothiocyanates with orthophenylenediamines [8][9][10] and methyl 2-(bromomethyl)-1H-benzimidazole-1-carboxylate with tosylmethylisocyanides [15][16][17], reaction of 4-O-[(triisopropylphenyl)sulfonyl]-pyrimidine nucleosides with orthophenylenediamine [18][19] and direct or biomedia reaction of deoxycytidine with p-benzoquinone [20][21][22][23][24][25][26][27]. Other routes include condensation of 2-(3-aminopropyl)-benzimidazole with carbon disulfide [28], 2-(2-benzimidazolyl)acetonitrile and 2-(2-benzimidazolyl)ethylacetate [29][30][31][32][33][34][35][36], ring construction of pyrimido [4,5-b]- [1,5]benzodiazepines [37][38][39], reaction of 6-chloro [1,3]oxazine-2,4-diones with orthophenylenediamine [40] and cyclocondensation of (benzimidazol-2-ylmethyl)-triphenylphosphonium chloride [41][42][43].…”