Synthesis, single-crystal characterization and preliminary biological evaluation of novel ferrocenyl pyrazolo[1,5-a]pyrazin-4(5H)-one derivatives

Bis(ferrocenylimine)palladium(II) and platinum(II) complexes: Synthesis, molecular structures and evaluation as antitumor agents

“…Furthermore, some ferrocenyl complexes have also been investigated for their anti-cancer activity, and exhibited promising cytotoxic activities [12][13]. The starting point in the development of new ferrocenyl derivatives as anticancer agents could be traced back to the discovery of the ferrocenium cation as an anticancer agent [14][15][16]. However literature reviews show conflicting conclusions about the important features in ferrocenyl compounds which could be responsible for their cytotoxic activities [12][13].…”

Investigation of potent anticarcinogenic activity of 1, 3-diarylpyrazole acrylamide derivatives in vitro

“…A variety of pyrazole derivatives have found to inhibit the proliferation of cancer cells. [23][24][25][26][27][28][29][30][31][32][33][34] In this work, we (c) Figure 4 Continued. found that 14 of 21 compounds reduced the viability of mesothelial and MM cells as compared to untreated (Figure 2) or DMSO-treated cells (data not shown).…”

“…Pyrazole‐acrylamide derivatives with characteristic chemical moieties could emerge with potentially enhanced therapeutic properties in the treatment of cancers . In our previous work, the viability of novel thiophene containing 1, 3‐diarylpyrazole derivatives has been investigated in breast cancer cell lines.…”

“…[20][21][22] Pyrazole-acrylamide derivatives with characteristic chemical moieties could emerge with potentially enhanced therapeutic properties in the treatment of cancers. [23][24][25][26][27][28][29][30] In our previous work, the viability of novel thiophene containing 1, 3-diarylpyrazole derivatives has been investigated in breast cancer cell lines. Derivative bearing benzylpiperidine group in the amide portion showed significant inhibitory effect against hematopoietic cancer cell lines.…”

Novel ferrocenyl derivatives exert anti-cancer effect in human lung cancer cells in vitro via inducing G1-phase arrest and senescence

“…We previously reported that novel ferrocenyl pyrazolo[1,5-a] pyrazin-4(5H)-one derivatives possess significant anti-tumor activity and induce cell cycle arrest [37] . To detect whether compounds 5b, 5d, and 5e induce cell cycle arrest in A549 cells, we performed flow cytometric analysis.…”