Synthesis, Reactivity and Biological Activity of Benzimidazoles

Crystal and Molecular Structure Study of the Complex Cd(L) 2Br2.C2H5OH (L=2-(4-Methylsulfanyl phenyl)-1H-benzimidazole)

“…The described methods for the synthesis of benzimidazoles make use of solid-phase synthesis via o-nitroanilines 3,4 or the condensation of o-phenylenediamines with carboxylic acid derivatives, aldehydes and aryl halides. Some of these derivatives, particularly nitro derivatives, are used as photographic materials in photography and on the other hand, the development of the chemistry of the benzimidazole dyes has been remarkable 5,6 .…”

Nucleophilic ring opening of 1,4-disubstituted 2-pyrrolidones with hydrazine. Synthesis of azoles with a high antibacterial activity

“…The synthesis of substituted benzimidazole derivatives is of considerable importance, because most of these compounds have a promising biological activity [1][2][3][4][5][6][7][8][9][10]. Also, the compounds whose molecules possess an azole ring, such as pyrrole [11][12][13], 1,3,4-oxadiazole [14][15][16][17][18][19] and 1,2,4-triazole [19][20][21][22][23], are often characterized as good antimicrobial agents.…”

Microwave-assisted synthesis of some 5(6)-nitro-1H-benzimidazoles and their hydrazide derivatives

“…Furthermore, various kinds of benzimidazole derivatives are found in diverse array of compounds, including biologically and therapeutically active agents [3], natural products [4]. Therefore, these compounds have been attracted attention of synthetic organic chemist.…”