Synthesis, radiolabeling, and preclinical in vivo evaluation of 68Ga-radiolabelled nanodiamonds

Wanek, Thomas; Mairinger, Severin; Raabe, Marco; Alam, Md. Noor; Filip, Thomas; Stanek, Johann; Winter, Gordon; Xu, Lujuan; Laube, Christian; Weil, Tanja; Rasche, Volker; Kuntner, Claudia

doi:10.1016/j.nucmedbio.2022.108310

Cited by 4 publications

(11 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The values from the gamma counter are summarized in Table 1 . In addition, the values from the previous study focusing on [ 68 Ga]Ga-DFO-ND [ 17 ] are shown in the table.…”

Section: Resultsmentioning

confidence: 99%

“…Radiolabeled nanodiamonds have emerged as innovative drug carriers with enhanced biocompatibility, a point underscored by the editorial board of the EJNMMI Radiopharmacy and Chemistry journal [ 18 ]. In a prior investigation, we developed a protocol for coating and radiolabeling nanodiamonds (NDs), assessing their in vivo pharmacokinetics in mice with tumors [ 17 ]. Due to the initially low tumor uptake, we devised strategies to enhance the tumor uptake, one of which involved functionalizing the NDs by incorporating a tumor-targeting moiety.…”

Section: Discussionmentioning

confidence: 99%

“…In a previous study [ 17 ], we explored the biodistribution of non-functionalized [ 68 Ga]Ga-DFO-ND. Despite including a targeting moiety in the present study, we did not observe increased ND uptake in the tumor compared to non-functionalized NDs ([ 68 Ga]Ga-DFO-ND: tumor 0.37 ± 0.10 %IA/g [ 17 ] versus [ 68 Ga]Ga-DFO-ND-Oct: tumor 0.32 ± 0.12 %IA/g).…”

Section: Discussionmentioning

confidence: 99%

“…In previous studies, we explored the potential of NDs for positron-emission tomo-graphy (PET) imaging [ 10 , 17 ]. In these studies, we coated NDs with cationized human serum albumin (cHSA) and polyethylene glycol (PEG) and added a chelator (DFO) for radiolabeling.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Functionalization of 68Ga-Radiolabeled Nanodiamonds with Octreotide Does Not Improve Tumor-Targeting Capabilities

Wanek,

Raabe,

Alam

et al. 2024

Pharmaceuticals

Self Cite

View full text Add to dashboard Cite

Nanodiamonds (NDs) are emerging as a novel nanoparticle class with growing interest in medical applications. The surface coating of NDs can be modified by attaching binding ligands or imaging probes, turning them into multi-modal targeting agents. In this investigation, we assessed the targeting efficacy of octreotide-functionalized 68Ga-radiolabelled NDs for cancer imaging and compared it with the tumor uptake using [68Ga]Ga-DOTA-TOC. In vivo studies in mice bearing AR42J tumors demonstrated the highest accumulation of the radiolabeled functionalized NDs in the liver and spleen, with relatively low tumor uptake compared to [68Ga]Ga-DOTA-TOC. Our findings suggest that, within the scope of this study, functionalization did not enhance the tumor-targeting capabilities of NDs.

show abstract

“…The values from the gamma counter are summarized in Table 1 . In addition, the values from the previous study focusing on [ 68 Ga]Ga-DFO-ND [ 17 ] are shown in the table.…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Functionalization of 68Ga-Radiolabeled Nanodiamonds with Octreotide Does Not Improve Tumor-Targeting Capabilities

Wanek,

Raabe,

Alam

et al. 2024

Pharmaceuticals

Self Cite

View full text Add to dashboard Cite

show abstract

“…For modern applications of nanodiamonds, the connection of complex molecules such as drugs, polymers, or sensor molecules plays an important role . Until now, for all medical investigations, the modification of NDs with complex molecules has been performed by wet chemistry, adsorption, polymer, or linker-induced grafting. , However, all these approaches have several challenges that limit the application of the resulting ND conjugates. Wet-chemical methods often require many chemicals and are based on multiple-step reactions, which are time- and cost-intensive.…”

Section: Introductionmentioning

confidence: 99%

Radiation Chemistry-Based Molecule Grafting: A Fast Track to Diamond-Based Hybrid Sensors

Laube,

Zwanck,

Hanisch

et al. 2024

Chem. Mater.

Self Cite

View full text Add to dashboard Cite

Nitrogen vacancy (NV) center-containing fluorescent nanodiamonds are promising quantum sensors for several industrial, medical, and biotechnological applications. A key factor in their applicability is their surface functionality, which can be modified in many ways. In this paper, we present primary results on a new approach for the synthesis of luminescent dye nanodiamond conjugates through an electron beam-induced radiation-chemical modification of nanodiamonds. This method involves grafting of fluorene and 9,10-dimethylanthracence. The successful modification is characterized using spectroscopic, microscopic, and mass spectrometric methods. The obtained results show that the radiation-chemical modification of nanodiamonds is fast and efficient and leads to a stable bonding of the molecule on the particle surface. For the 9,10-dimethylanthracence conjugate, a wavelength-selective excitation of the fluorescent dye and NV center inside the nanodiamond could be demonstrated. The fast radiation chemistry-based synthesis of new nanodiamond conjugates could be used to manufacture multiparameter hybrid sensor particles, with a high impact on sensor technology, medicine, and biotechnology.

show abstract

Highlight selection of radiochemistry and radiopharmacy developments by editorial board

DaSilva,

Decristoforo,

Mach

et al. 2023

EJNMMI radiopharm. chem.

View full text Add to dashboard Cite

Background The Editorial Board of EJNMMI Radiopharmacy and Chemistry releases a biannual highlight commentary to update the readership on trends in the field of radiopharmaceutical development. Main body This selection of highlights provides commentary on 21 different topics selected by each coauthoring Editorial Board member addressing a variety of aspects ranging from novel radiochemistry to first-in-human application of novel radiopharmaceuticals. Conclusion Trends in radiochemistry and radiopharmacy are highlighted. Hot topics cover the entire scope of EJNMMI Radiopharmacy and Chemistry, demonstrating the progress in the research field in many aspects.

show abstract

Synthesis, radiolabeling, and preclinical in vivo evaluation of 68Ga-radiolabelled nanodiamonds

Cited by 4 publications

References 30 publications

Functionalization of 68Ga-Radiolabeled Nanodiamonds with Octreotide Does Not Improve Tumor-Targeting Capabilities

Functionalization of 68Ga-Radiolabeled Nanodiamonds with Octreotide Does Not Improve Tumor-Targeting Capabilities

Radiation Chemistry-Based Molecule Grafting: A Fast Track to Diamond-Based Hybrid Sensors

Highlight selection of radiochemistry and radiopharmacy developments by editorial board

Contact Info

Product

Resources

About