Synthesis, properties, and biomedical applications of alginate methacrylate (ALMA)-based hydrogels: Current advances and challenges

Hasany, Masoud; Talebian, Sepehr; Sadat, Seyedmostafa; Ranjbar, Navid; Sadeghinezhad, Emad; Wallace, Gordon G.; Mehrali, Mehdi

doi:10.1016/j.apmt.2021.101150

Cited by 41 publications

(40 citation statements)

References 141 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results showed mechanical properties in the same order of magnitude for the 0.2 S-PEG and 0.1 DTT hydrogels in terms of storage modulus (E′), ultimate compression strength, and deformation at break (See Figure 6 C). Moreover, the absolute mechanical values reported here were comparable to or higher than those of other proposed alginate hydrogels obtained using methacrylates [ 72 , 73 ] or thiol–ene reactions [ 36 ]. The better values obtained for 0.2 S-PEG with respect to 0.1 DTT could be attributed to the more homogeneous network, as was also observed in the FESEM images, and to the more deformable crosslinked structure (due to the higher molecular weight of the PEG crosslinker).…”

Section: Resultssupporting

confidence: 83%

Photocurable Thiol–yne Alginate Hydrogels for Regenerative Medicine Purposes

et al. 2022

View full text Add to dashboard Cite

Every year millions of people worldwide undergo surgical interventions, with the occurrence of mild or severe post-treatment consequences meaning that rehabilitation plays a key role in modern medicine. Considering the cases of burns and plastic surgery, the pressing need for new materials that can be used for wound patches or body fillers and are able to sustain tissue regeneration and promote cell adhesion and proliferation is clear. The challenges facing next-generation implant materials also include the need for improved structural properties for cellular organization and morphogenic guidance together with optimal mechanical, rheological, and topographical behavior. Herein, we propose for the first time a sodium alginate hydrogel obtained by a thiol–yne reaction, easily synthesized using carbodiimide chemistry in a two-step reaction. The hydrogels were formed in all cases within a few minutes of light irradiation, showing good self-standing properties under solicitation. The mechanical, rheological, topographical, and swelling properties of the gels were also tested and reported. Lastly, no cytotoxicity was detected among the hydrogels. Soluble extracts in culture media allowed cell proliferation, and no differences between samples were detected in terms of metabolic activity and DNA content. These results suggest the potential use of these cytocompatible hydrogels in tissue engineering and regenerative medicine.

show abstract

Section: Resultssupporting

confidence: 83%

Photocurable Thiol–yne Alginate Hydrogels for Regenerative Medicine Purposes

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Modified alginate matrixes have been used extensively for tissue engineering and drug delivery [ 44 ], but are less commonly used for tumor models than GelMA and HA-MA, perhaps due to the importance of enzyme-mediated degradation in tumor progression [ 45 ]. Examples of modified alginates used as tumor models include the work from Fischbach et al which examined the impact of the presence of RGD and 2D vs. 3D culture on oral squamous cell carcinoma growth factor secretion [ 46 ], and Grigore et al’s study on the impact of the addition of RGD and gelatin to covalently crosslinked hydrogels on the behavior of osteosarcoma cells [ 47 ].…”

Section: Commonly Used Materialsmentioning

confidence: 99%

Reductionist Three-Dimensional Tumor Microenvironment Models in Synthetic Hydrogels

Katz

West

2022

Cancers

View full text Add to dashboard Cite

The tumor microenvironment (TME) plays a determining role in everything from disease progression to drug resistance. As such, in vitro models which can recapitulate the cell–cell and cell–matrix interactions that occur in situ are key to the investigation of tumor behavior and selecting effective therapeutic drugs. While naturally derived matrices can retain the dimensionality of the native TME, they lack tunability and batch-to-batch consistency. As such, many synthetic polymer systems have been employed to create physiologically relevant TME cultures. In this review, we discussed the common semi-synthetic and synthetic polymers used as hydrogel matrices for tumor models. We reviewed studies in synthetic hydrogels which investigated tumor cell interactions with vasculature and immune cells. Finally, we reviewed the utility of these models as chemotherapeutic drug-screening platforms, as well as the future directions of the field.

show abstract

“…[ 153 ] In 1987, Stevenson and Sefton grafted hydroxyethyl methacrylate onto an alginate backbone via γ ‐radiation, and the material was then used for microencapsulation of red blood cells. [ 154 ] These works were the beginning of a new era in which alginates were put at the forefront of hydrogels for biomedical applications. Combined with its biodegradability, biocompatibility, nonantigenicity, and chelating ability, alginates have been widely used in the assembly of hydrogels for biomimetic applications such as tissue engineering of soft and bone tissue, in addition to wound healing and drug delivery.…”

Section: Alginatesmentioning

confidence: 99%

Biomimetic Biomaterials Based on Polysaccharides: Recent Progress and Future Perspectives

Silva

Carvalho

Moraes

et al. 2022

Macro Chemistry & Physics

View full text Add to dashboard Cite

Nature is a source of diverse materials, including polysaccharides, which have been used to improve the quality of life. Besides being abundant and renewable, polysaccharides possess many advantages, such as biodegradability and biocompatibility, which allow them to be applied in different fields. They can be used in the design and development of renewable materials, thus contributing to a more sustainable society. Because of their advantages and versatility, polysaccharides may be incorporated in many systems, particularly biomimetic ones, to create outstanding sustainable solutions to problems that still need to be solved. Hence, nature not only offers resources but an inspiration to overcome issues. In this sense, this work aims to present an overview of current relevant biomimetic systems based on polysaccharides. Chitosan, cellulose, xanthan gum, alginates, pullulan, hyaluronic acid, schizophyllan, and oligomeric cyclodextrins are covered. The application of these polysaccharides in the design of biosensors, systems for environmental remediation, structural materials, drug delivery systems, tissue engineering among others is described. Finally, the challenges that still need to be faced and opportunities of application of these materials for the development of bioinspired technologies in the next future are highlighted.

show abstract

Synthesis, properties, and biomedical applications of alginate methacrylate (ALMA)-based hydrogels: Current advances and challenges

Cited by 41 publications

References 141 publications

Photocurable Thiol–yne Alginate Hydrogels for Regenerative Medicine Purposes

Photocurable Thiol–yne Alginate Hydrogels for Regenerative Medicine Purposes

Reductionist Three-Dimensional Tumor Microenvironment Models in Synthetic Hydrogels

Biomimetic Biomaterials Based on Polysaccharides: Recent Progress and Future Perspectives

Contact Info

Product

Resources

About