Synthesis, properties and applications of new (bio)degradable polyester urethanes

Abstract

Artyku³ stanowi przegl¹d literaturowy dotycz¹cy badañ nad syntez¹ i wybranymi w³aoeciwooeciami dwóch grup nowych (bio)degradowalnych poliestrouretanów, których segmenty giêtkie za-wiera³y zsyntezowane telecheliczne oligoestrodiole: ataktyczny poli([R,S]-3-hydroksymaoelan) (a-PHB) lub polilaktyd (PLA) i/lub alifatyczno-aromatyczny kopolimer poli[(tereftlanu-1,4-butylenu)-co-(adypinianu-1,4-butylenu)] (BTA). Przytoczone wyniki wskazuj¹, ¿e poliestrouretany pierwszej grupy s¹ podatne na degradacjê w oerodowisku hydrolitycznym i utleniaj¹cym. Odpowiednio modyfikowane wyka-zuj¹ potencjaln¹ biostatycznooeae i hemokompatybilnooeae. Druga grupa poliestrouretanów ³¹czy w³aoeciwooeci obu polimerów, z których otrzymano oligoestrodiole: PLA i BTA, co jest korzystne ze wzglêdu na w³aoeciwooeci mechaniczne oraz podatnooeae na degradacjê, potwierdzon¹ w badaniach prowadzonych w warunkach kompostowania przemys³owego.S³owa kluczowe: poliestrouretany, ataktyczny poli([R,S]-3-hydroksymaoelan) (a-PHB), polilaktyd (PLA), alifatyczno-aromatyczny kopolimer poli[(tereftalan-1,4-butylenu)-co-(adypinian-1,4-butylenu)] (BTA).Nr 5 MAJ 2014

Polyurethanes Based on Atactic Poly[(R,S)-3-hydroxybutyrate]: Preliminary Degradation Studies in Simulated Body Fluids

“…The sample mass was reduced by about 61 % [8]. However, the weight loss of polyurethane samples after the degradation in SBF was lower than in the case of degradation in mentioned phosphate buffer.…”

“…The samples studied were obtained at our laboratories as described previously [7,13]. Synthesis of polyurethanes was carried out in a two-step reaction, with molar ratio of NCO:OH = 3.7:1 or 2:1, respectively, at prepolymerization stage.…”

“…Previous work showed that the presence of a-PHB in polyurethane network influences their structural, thermal, mechanical and degradation properties [7][8][9][10]. Polyurethanes based on a-PHB do not affect the blood parameters in direct contact and seem to be biostatic against pathogenic microorganisms [10][11][12].…”

The structure of novel polyurethanes containing synthetic poly[(R,S)‐3‐hydroxybutyrate]

“…According to potential application of these polyurethanes as degradable material for medical engineering or in drug delivery system low molar masses can accelerate degradation processes in living body. Thermal properties of obtained polyurethanes,5 indicating on their low crystallinity, suggest their potential degradability 6, 7…”

“…Synthesis of polyurethanes was carried out in a two‐step reaction at the vacuum reactor, as described previously 5. First, the prepolymer was prepared from polyols and H 12 MDI, in a presence of catalyst (DBTDL), at reduced pressure (1,4 hPa) according to molar ratio of NCO : OH groups indicated in Table I.…”