Synthesis, physicochemical, rheological and in-vitro characterization of double-crosslinked hyaluronic acid hydrogels containing dexamethasone and PLGA/dexamethasone nanoparticles as hybrid systems for specific medical applications

Nejad, Zohre Mousavi; Torabinejad, Bahman; Davachi, Seyed Mohammad; Zamanian, Ali; Garakani, Sadaf Saeedi; Najafi, Farhood; Nezafati, Nader

doi:10.1016/j.ijbiomac.2018.12.181

Cited by 43 publications

(12 citation statements)

References 60 publications

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“…The frequency sweep tests at 1% strain in the linear region were carried out [50]. Figure 4g shows the G’ of hydrogels without Nafcillin in the frequency sweep test.…”

Section: Resultsmentioning

confidence: 99%

3D Bioprinting of the Sustained Drug Release Wound Dressing with Double-Crosslinked Hyaluronic-Acid-Based Hydrogels

Xing²,

Ding

et al. 2019

Polymers

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Hyaluronic acid (HA)-based hydrogels are widely used in biomedical applications due to their excellent biocompatibility. HA can be Ultraviolet (UV)-crosslinked by modification with methacrylic anhydride (HA-MA) and crosslinked by modification with 3,3′-dithiobis(propionylhydrazide) (DTP) (HA-SH) via click reaction. In the study presented in this paper, a 3D-bioprinted, double-crosslinked, hyaluronic-acid-based hydrogel for wound dressing was proposed. The hydrogel was produced by mixing HA-MA and HA-SH at different weight ratios. The rheological test showed that the storage modulus (G’) of the HA-SH/HA-MA hydrogel increased with the increase in the HA-MA content. The hydrogel had a high swelling ratio and a high controlled degradation rate. The in vitro degradation test showed that the hydrogel at the HA-SH/HA-MA ratio of 9:1 (S9M1) degraded by 89.91% ± 2.26% at 11 days. The rheological performance, drug release profile and the cytocompatibility of HA-SH/HA-MA hydrogels with loaded Nafcillin, which is an antibacterial drug, were evaluated. The wound dressing function of this hydrogel was evaluated by Live/Dead staining and CCK-8 assays. The foregoing results imply that the proposed HA-SH/HA-MA hydrogel has promise in wound repair applications.

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“…The frequency sweep tests at 1% strain in the linear region were carried out [50]. Figure 4g shows the G’ of hydrogels without Nafcillin in the frequency sweep test.…”

Section: Resultsmentioning

confidence: 99%

3D Bioprinting of the Sustained Drug Release Wound Dressing with Double-Crosslinked Hyaluronic-Acid-Based Hydrogels

Xing²,

Ding

et al. 2019

Polymers

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“…The cytotoxicity study using MTT assay on the hydrogels demonstrated high cell viability of HFFF2 human fibroblast cells. These results also revealed that HA hydrogels are suitable for wound care [ 73 ].…”

Section: Bioactive Agents Loaded Hyaluronic Acid Scaffoldsmentioning

confidence: 96%

Hyaluronic Acid-Based Scaffolds as Potential Bioactive Wound Dressings

Alven

Aderibigbe

2021

Polymers

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The negative factors that result in delayed and prolonged wound healing process include microbial pathogens, excess wound exudates, underlying conditions, smoking, obesity, etc. Most of the currently used wound dressings demonstrate an inadequate capacity to treat wounds resulting from the factors mentioned above. The commonly used wound dressings include hydrogels, films, hydrocolloids, foams, fibers, sponges, dermal patches, bandages, etc. These wound dressings can be loaded with various types of bioactive agents (e.g., antibiotics, nanoparticles, anti-inflammatory drugs, etc.) to improve their therapeutic outcomes. Biopolymers offer interesting properties suitable for the design of wound dressings. This review article will be based on hyaluronic-acid-based scaffolds loaded with therapeutic agents for the treatment of wounds.

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“…Researchers conducted numerous studies to recognize highly effective approaches (such as barrier‐based devices and pharmacological) or ideal materials to prevent PPAs. [ 12 ] By the use of pharmaceutical active ingredients or drugs such as nonsteroidal anti‐inflammatory drugs (NSAIDs) [ 12,18 ] and dexamethasone, which interfere with specific cytokines or vascular permeability, [ 19,20 ] and heparin, and others have previously used for the prevention of PPAs. Still, most of them are to achieve satisfactory results.…”

Section: Introductionmentioning

confidence: 99%

Advancement of Biomaterial‐Based Postoperative Adhesion Barriers

Chandel

Shimizu

Hasegawa

et al. 2021

Macromolecular Bioscience

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Postoperative peritoneal adhesion (PPA) is a prevalent incidence that generally happens during the healing process of traumatized tissues. It causes multiple severe complications such as intestinal obstruction, chronic abdominal pain, and female infertility. To prevent PPA, several antiadhesion materials and drug delivery systems composed of biomaterials are used clinically, and clinical antiadhesive is one of the important applications nowadays. In addition to several commercially available materials, like film, spray, injectable hydrogel, powder, or solution type have been energetically studied based on natural and synthetic biomaterials such as alginate, hyaluronan, cellulose, starch, chondroitin sulfate, polyethylene glycol, polylactic acid, etc. Moreover, many kinds of animal adhesion models, such as cecum abrasion models and unitary horn models, are developed to evaluate new materials’ efficacy. A new animal adhesion model based on hepatectomy and conventional animal adhesion models is recently developed and a new adhesion barrier by this new model is also developed. In summary, many kinds of materials and animal models are studied; thus, it is quite important to overview this field's current progress. Here, PPA is reviewed in terms of the species of biomaterials and animal models and several problems to be solved to develop better antiadhesion materials in the future are discussed.

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Synthesis, physicochemical, rheological and in-vitro characterization of double-crosslinked hyaluronic acid hydrogels containing dexamethasone and PLGA/dexamethasone nanoparticles as hybrid systems for specific medical applications

Cited by 43 publications

References 60 publications

3D Bioprinting of the Sustained Drug Release Wound Dressing with Double-Crosslinked Hyaluronic-Acid-Based Hydrogels

3D Bioprinting of the Sustained Drug Release Wound Dressing with Double-Crosslinked Hyaluronic-Acid-Based Hydrogels

Hyaluronic Acid-Based Scaffolds as Potential Bioactive Wound Dressings

Advancement of Biomaterial‐Based Postoperative Adhesion Barriers

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