Synthesis, physicochemical characterization and biological activity of nano complexes of iron(III) of 3(2'‐hydroxyphenyl)‐5‐(4′‐substituted phenyl) pyrazolines and aspartic acid

Abstract

= deprotonated 3(2′hydroxyphenyl)-5-(4′-substituted phenyl) pyrazolines (X = H, CH 3 , OCH 3 , Cl), have been synthesized. These newly synthesized derivatives have been physicochemically characterized by elemental analysis (C, H, N, Cl and Fe), magnetic moment data, thermogravimetric analysis, molar conductance, cyclic voltammetry, spectral analysis (UV-visible, IR, far IR and fast atom bombardment mass spectrometry). Scanning electron microscopy, transmission electron microscopy and X-ray powder diffraction studies have been carried out for powdered samples, which show nanometric particles of these derivatives. Antibacterial and antifungal potential of free pyrazoline and some iron(III) complexes have been evaluated.

Synthesis, physicochemical characterization, and biological activity of nanocomplexes of iron(III) of 3(2′-hydroxyphenyl)-5-(4-substituted phenyl) pyrazolines and dithiophosphoric acid

“…Thus, the complexes may be used as precursors of antibiotic and antifungal drugs after testing in vitro. [16,38,39]. Complexes of iron(III) with pyrazoline and dithiophosphoric acid and with pyrazoline and aspartic acid show comparable activity against P. chrysogenum [16].…”

“…Because of significant antimicrobial activities of these complexes, they have been used as precursors of antibiotic and antifungal drugs after testing in vitro. The structure-activity relationship of iron complexes of the type [Fe(C 6 [38], ethylene glycol, and pyrazolines [39], as well as with pyrazolines and aspartic acid [16]. If we consider activity against P. chrysogenum, the complexes show comparable activity to complexes of iron(III) with pyrazoline and aspartic acid [16].…”

“…The structure-activity relationship of iron complexes of the type [Fe(C 6 [38], ethylene glycol, and pyrazolines [39], as well as with pyrazolines and aspartic acid [16]. If we consider activity against P. chrysogenum, the complexes show comparable activity to complexes of iron(III) with pyrazoline and aspartic acid [16]. In many cases, metal complexes of ligands which have biological activity are more active than free ligands [42,43] and our complexes also show much more activity than the free pyrazolines [38].…”

“…3(2′-Hydroxyphenyl)-5-(4-X-phenyl pyrazolines) and substituted pyrazolines with iron(III) have been studied. Synthesis, physicochemical characterization, and biological activity of nanocomplexes of iron(III) of 3(2′-hydroxyphenyl)-5-(4-substituted phenyl) pyrazolines and aspartic acid have also been carried out by Tripathi et al [16]. In this article, we describe synthesis, characterization, and in vitro antimicrobial activity of mixed ligand complexes of iron(III) with dithiophosphoric acid and 3(2′-hydroxyphenyl)-5-(4-substituted phenyl) pyrazolines.…”