Synthesis, physicochemical characterisation and cytotoxic screening of new complexes of cerium, lanthanum and neodymium with Warfarin and Coumachlor sodium salts

Kostova, Irena; Manolov, Ilia; Konstantinov, Spiro; Karaivanova, Margarita

doi:10.1016/s0223-5234(99)80041-5

Cited by 77 publications

(47 citation statements)

References 11 publications

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“…The complexes have revealed good anticoagulant action. As a result of our earlier work, the cytotoxic profile of some complexes of Warfarin and Coumachlor with lanthanides was proved [3,4] . Other authors have reported the synthesis and characterization of coumarin derivatives' complexes with lanthanides without commenting about their pharmacological properties.…”

Section: Introductionmentioning

confidence: 88%

Cytotoxic Activity of Cerium Complexes with Coumarin Derivatives. Molecular Modeling of the Ligands

Manolov

Kostova

Netzeva

et al. 2000

Arch. Pharm. Pharm. Med. Chem.

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Section: Introductionmentioning

confidence: 88%

Cytotoxic Activity of Cerium Complexes with Coumarin Derivatives. Molecular Modeling of the Ligands

Manolov

Kostova

Netzeva

et al. 2000

Arch. Pharm. Pharm. Med. Chem.

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“…The complexes have revealed good anticoagulant action. As a result from our earlier work the cytotoxic profile of some complexes of mendiaxon, warfarin, coumachlor, and niffcoumar with lanthanides against P3HR1, K-562, and THP-1 cell lines was proved [10][11][12] .…”

Section: Introductionmentioning

confidence: 90%

Synthesis, Physicochemical Characterization, and Cytotoxic Screening of New Zirconium Complexes with Coumarin Derivatives

Kostova

Manolov

Karaivanova

2001

Arch. Pharm. Pharm. Med. Chem.

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Zirconium complexes of mendiaxon, warfarin, coumachlor, and niffcoumar have been synthesized by reaction of the ligands with zirconium chloride in stoichiometric ratio 1:2. The formation of the complexes has been proved on the basis of elemental analysis, IR‐spectroscopy, 1H‐NMR spectroscopy, and thermal studies. Differential thermal analyses and thermogravimetric analyses have been applied to study the compositions of the new complexes. It is concluded that the lactone‐ and the keto‐carbonyl groups of warfarin, coumachlor, and niffcoumar are bonded to the metal ion as bidentate ligands, but mendiaxon is bonded as monodentate ligand. Cytotoxic screening by MTT‐assay was carried out. Among these compounds the zirconium complex of mendiaxon showed highest cytotoxic activity against human promyelocytic leukemic HL‐60 cells. The inorganic salt was found to be active against this cell line.

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“…Each data point represents the mean ± SD (n ≥ 6). new Ce(III) and Nd(III) complexes show the practically equivalent relative potencies (in terms of IC 50 ) with the referent drug cisplatin. This encounter could be generally ascribed to the well-established high level of bcl-2 expression in DOHH-2 cells.…”

Section: Pharmacologymentioning

confidence: 96%

New cerium(III) and neodymium(III) complexes as cytotoxic agents

Kostova

Rastogi

Kiefer

et al. 2006

Appl. Organometal. Chem.

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The cerium(III) and neodymium(III) complexes of 5-aminoorotic acid were synthesized and characterized by means of spectral data (IR, Raman, 1 H NMR and 13 C NMR) and elemental analysis. Significant differences in the IR spectra of the complexes were observed as compared with the spectrum of the ligand. A comparative analysis of the Raman spectra of the complexes with that of the free 5-aminoorotic acid allowed a straightforward assignment of the vibrations of the ligand groups involved in coordination. 1 H NMR and 13 C NMR spectra confirmed the formation of the complexes. The ligand and the complexes were tested for the cytotoxic activities on the chronic myeloid leukemia-derived K-562, overexpressing the BCR-ABL fusion protein, and the non-Hodgkin lymphoma-derived DOHH-2, characterized by a rexpression of the antiapoptotic protein bcl-2 cell lines. The results obtained indicate that the tested compounds exerted a considerable cytotoxic activity upon the evaluated cell lines in a concentration-dependent manner, which enabled the construction of dose-response curves and the calculation of the corresponding IC 50 values. Cytotoxicity towards tumor cells was determined for a broad concentration range. The inorganic salts exerted a very weak cytotoxic effect on these cells that is in contrast to the lanthanide complexes, which exhibited potent cytotoxic activity towards K-562 and DOHH-2 cell lines.

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Synthesis, physicochemical characterisation and cytotoxic screening of new complexes of cerium, lanthanum and neodymium with Warfarin and Coumachlor sodium salts

Cited by 77 publications

References 11 publications

Cytotoxic Activity of Cerium Complexes with Coumarin Derivatives. Molecular Modeling of the Ligands

Cytotoxic Activity of Cerium Complexes with Coumarin Derivatives. Molecular Modeling of the Ligands

Synthesis, Physicochemical Characterization, and Cytotoxic Screening of New Zirconium Complexes with Coumarin Derivatives

New cerium(III) and neodymium(III) complexes as cytotoxic agents

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