Synthesis, physicochemical and biological characterization of Ni(II) complex with imidazole-4-acetate anion as new antifungal agent

Gałczyńska, Katarzyna; Kurdziel, Krystyna; Ciepluch, Karol; Rachuna, Jarosław; Kowalska, Magdalena; Madej, Łukasz; Węgierek-Ciuk, Aneta; Lankoff, Anna; Arabski, Michał

doi:10.1007/s12039-018-1574-5

Cited by 4 publications

(3 citation statements)

References 27 publications

(25 reference statements)

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“…In this experiment we used a high resolution melting (HRM) procedure (PCR-based technique), to analyse the melting temperature of amplicon/tested chemical agent complex formed after DNA incubation with metal complexes. This application of PCR-HRM technique was described in detail in our previously work 20 . The analysed agents might interact with DNA intercalated by SYBR Green I dye.…”

Section: Resultsmentioning

confidence: 99%

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Selective cytotoxicity and antifungal properties of copper(II) and cobalt(II) complexes with imidazole-4-acetate anion or 1-allylimidazole

Gałczyńska

Ciepluch

Madej

et al. 2019

Sci Rep

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The physicochemical properties of metal complexes determine their potential applications as antitumor agents. In this study, the antitumor properties of mononuclear cobalt(II) and copper(II) coordination compounds (stoichiometry: [Co(iaa) 2 (H 2 O) 2 ]·H 2 O (iaa = imidazole-4-acetate anion), [Co(1-allim) 6 ](NO 3 ) 2 (1-allim = 1-allylimidazole), [Cu(iaa) 2 H 2 O] and [Cu(1-allim) 4 (NO 3 ) 2 ]) and their ligands have been evaluated on human lung carcinoma A549 cells and normal bronchial BEAS-2B cells. Designing the chemical structure of new antitumor agents the possible interactions with macromolecules such as DNA or proteins should be take into account. PCR gene tlr4 product served as DNA model, whereas lysozyme and phage-derived endolysin (both peptidoglycan degrading enzymes) were applied as protein/enzyme model. The interactions were analysed using PCR-HRM and circular dichroism, FT-IR, spectrophotometry, respectively. Additionally, the antimicrobial properties of the complexes at a non-cytotoxic concentration were analyzed against S. aureus, E. coli, P. aeruginosa and C. albicans strains. The results obtained in this study showed the selective cytotoxicity of metal complexes, mainly [Cu(1-allim) 4 (NO 3 ) 2 ] towards tumor cells. From all tested compounds, only [Co(iaa) 2 (H 2 O) 2 ] . H 2 O non-covalently interacts with DNA. Cu(II) and Co(II) complexes did not affect the secondary conformation of tested proteins but modified the hydrolytic activity of enzymes (lysozyme and endolysin). Moreover, only [Co(iaa) 2 (H 2 O) 2 ] . H 2 O exhibited the antifungal properties. In conclusion, Co(II) and Cu(II) metal complexes bearing two imidazole-4-acetate ligands seemed to be promising antitumor and antifungal agents for future drug design and application.

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Section: Resultsmentioning

confidence: 99%

“…The effect of metal complexes on DNA was measured by polymerase chain reaction (PCR) with high resolution melting (HRM) using LightCycler 480 II (Hoffman-LaRoche, Switzerland) 20 . The PCR-HRM was performed according to manufacturer instructions using LightCycler 480 SYBR Green I Master (Hoffman-LaRoche, Switzerland).…”

Section: Methodsmentioning

confidence: 99%

Selective cytotoxicity and antifungal properties of copper(II) and cobalt(II) complexes with imidazole-4-acetate anion or 1-allylimidazole

Gałczyńska

Ciepluch

Madej

et al. 2019

Sci Rep

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“…In terms of complexes, they have been increasingly researched for their good hydrophilicity, bioavailability, and other advantages, revealing their unique value within antifungal medicinal science. In recent years, research toward developing imidazole-based complexes as antifungal agents has shown an increasing tendency [ 373 , 374 ].…”

Section: Imidazole-based Supermolecules As Medicinal Agentsmentioning

confidence: 99%

Comprehensive Insights into Medicinal Research on Imidazole-Based Supramolecular Complexes

Tan

Zhang

et al. 2023

Pharmaceutics

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The electron-rich five-membered aromatic aza-heterocyclic imidazole, which contains two nitrogen atoms, is an important functional fragment widely present in a large number of biomolecules and medicinal drugs; its unique structure is beneficial to easily bind with various inorganic or organic ions and molecules through noncovalent interactions to form a variety of supramolecular complexes with broad medicinal potential, which is being paid an increasing amount of attention regarding more and more contributions to imidazole-based supramolecular complexes for possible medicinal application. This work gives systematical and comprehensive insights into medicinal research on imidazole-based supramolecular complexes, including anticancer, antibacterial, antifungal, antiparasitic, antidiabetic, antihypertensive, and anti-inflammatory aspects as well as ion receptors, imaging agents, and pathologic probes. The new trend of the foreseeable research in the near future toward imidazole-based supramolecular medicinal chemistry is also prospected. It is hoped that this work provides beneficial help for the rational design of imidazole-based drug molecules and supramolecular medicinal agents and more effective diagnostic agents and pathological probes.

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Influence of pH on the structures of two Cd phosphonate compounds

et al. 2020

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Synthesis, physicochemical and biological characterization of Ni(II) complex with imidazole-4-acetate anion as new antifungal agent

Cited by 4 publications

References 27 publications

Selective cytotoxicity and antifungal properties of copper(II) and cobalt(II) complexes with imidazole-4-acetate anion or 1-allylimidazole

Selective cytotoxicity and antifungal properties of copper(II) and cobalt(II) complexes with imidazole-4-acetate anion or 1-allylimidazole

Comprehensive Insights into Medicinal Research on Imidazole-Based Supramolecular Complexes

Influence of pH on the structures of two Cd phosphonate compounds

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