Synthesis, physico-chemical investigations and biological studies on Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes with p -amino acetophenone isonicotinoyl hydrazone

Abstract

Complexes of the type [M(painh)(H 2 O) 2 X], where M ¼ Mn(II), Co(II), Ni(II), Cu(II) and Zn(II); X ¼ Cl 2 or SO 4 ; painh ¼ p-amino acetophenone isonicotinoyl hydrazone, have been synthesized and characterized by spectral and other physico-chemical techniques. The synthesized complexes are stable powders, insoluble in common organic solvents such as ethanol, benzene, carbon tetrachloride, chloroform and diethyl ether, and are non-electrolytes. Thermogravimetric Analysis (TGA) and Differential Thermal Analysis (DTA) studies show that the organic ligand decomposes exothermically through various steps. TGA and Infrared (IR) spectral studies indicate the presence of coordinated water in the metal complexes. Magnetic susceptibility measurements and electronic spectra suggest that Mn(II), Co(II), and Ni(II) complexes are paramagnetic with octahedral geometry, whereas Cu(II) complexes have distorted octahedral geometry. The neutral bidentate ligand bonds through4C¼O and4C¼N-groups in all the complexes. Electron Spin Resonance (ESR) spectra in the solid state show axial symmetry for [Cu(painh)(H 2 O) 2 (SO 4 )] and elongated rhombic symmetry for [Cu(painh)(H 2 O) 2 Cl 2 ], suggesting an elongated tetragonally-distorted octahedral structure for both complexes. X-ray powder diffraction parameters for two complexes correspond to tetragonal and orthorhombic crystal lattices. The metal complexes show fair antifungal activity against Rizoctonia sp., Aspergillus sp., Stemphylium sp., and Penicillium sp. and appreciable antibacterial activity against Pseudomonas sp. and Escherichia coli.

Metal complexes of N'-(2-hydroxy-5-phenyldiazenyl) benzylideneisonicotinohydrazide: Synthesis, spectroscopic characterization and antimicrobial activity

“…The metal complexes were prepared by mixing a hot ethanolic solution of the required metal acetate: Cu(CH 3 COO) 2 presence of 2 mL of triethylamine (TEA). The reaction mixture was then refluxed for a time depending on the metal salt used (2-4 h).…”

Synthesis and characterization of a binuclear copper(II) complex [Cu(H2slox)]2 from polyfunctional disalicylaldehyde oxaloyldihydrazone and its heterobinuclear copper(II) and molybdenum(VI) complexes

“…A survey of literature reveals that although work on metal complexes of monohydrazide-based ligands and their Schiff bases has been carried out in some detail [18][19][20][21], those on metal complexes of dihydrazones are quite meager [16,17,[22][23][24][25][26][27]. It further reveals that work on heterobimetallic complexes of dihydrazones is virtually absent [26,27].…”

Synthesis, characterization, and biological activity studies of copper(II)–metal(II) binuclear complexes of dipyridylglyoxal bis(2-hydroxybenzoyl hydrazone)

“…but moderate antibacterial activity against E. coli and Clostridium sp. Furthermore, the complexes of p-aminoacetophenone isonicotinoyl hydrazone [38] showed fair antifungal activity against Rizoctonia sp., Aspergillus sp., Stemphylium sp., and Penicillium sp. and appreciable antibacterial activity against Pseudomonas sp.…”