Synthesis, physico-chemical characterization and biological activity of 2-aminobenzimidazole complexes with different metal ions

Abstract

Complexes of 2-aminobenzimidazole (L) with nitrates of cobalt(II) nickel(II), copper (II), zinc(II) and silver(I) were synthesized. The molar ratio metal:ligand in the reaction of the complex formation was 1:2. It should be noticed, that the reaction of all the metal salts yielded bis(ligand) complexes of the general formula M(L)2(NO3)2 × nH2O (M=Co, Ni Cu, Zn or Ag; n=0, 1, 2 or 6). The complexes were characterized by elemental analysis of the metal, molar conductivity, magnetic susceptibility measurements and IR spectra. Co(II), Ni(II) and Cu(II) complexes behave as non-electrolytes, whilst Zn(II) and Ag(I) are 1:1 electrolytes. Cu(II) complex has a square-planar stereochemistry, Ag(I) complex is linear, whilst the Co(II), Ni(II) and Zn(II) complexes have a tetrahedral configuration. In all the complexes ligand is coordinated by participation of the pyridine nitrogen of the benzimidazole ring. The antimicrobial activity of the ligand and its complexes against Pseudomonas aeruginosa, Bacillus sp. Staphylococcus aureus and Saccharomyces cerevisiae was investigated. The effect of metal on the ligand antimicrobial activity is discussed

Synthesis, Characterization and Biological Evaluation of New Dithiocarbamate Ligand and Its Complexes with some Metal Ions

“…"The bands at 3062 cm -1 and 2990, 2943 cm -1 attributed to the υ(C-H) aromatic and υ(C-H) aliphatic stretching vibration respectively". "The bands observed at 1630 cm -1 and 1587cm -1 were assigned to υ (C=N) and υ aromatic (C=C) mode of aromatic system respectively" [19]. "While the band observed at 1271 cm -1 recorded to υ (C-N) stretching vibration" [20].…”

“…detected at 2939 cm -1" [19]. Also the IR spectrum exhibited broad band at 3471cm -1 and new' band at 816cm -1 that may be attributed to υ(OH) and δ(OH) respectively which refer to coordinated H 2 O molecule (aqua) with Co-complex in molecular formula [29].…”

Synthesis, spectral characterization, thermal analysis and DFT computational studies of 2-(1H-indole-3-yl)-5-methyl-1H-benzimidazole and their Cu(II), Zn(II) and Cd(II) complexes

“…The reaction carried out in air under reflux or in room temperature in presence an oxative reagent such as H2O2 [3], Pb(OAC)2 [4], or in presence a catalyst such as cupric acetate [5]. The complexes of transition metals with benzimidazole have been extensively studied due to the ability of benzimidazoles as excellent N-donor ligands [6]. Most of benzimidazoles possess antibacterial, fungicide, antihelmintic and antitumor activity [7].…”

Complexing Behaviour and Antifungal Activity of N-[(1E)-1-(1H-Benzimidazol-2-yl)ethylidene]morpholine-4-carbothiohydrazide and Related Ligand with Metal Ions

“…Preparation and structural aspects of various metal ions with a number of benzimidazole derivatives have been reported by one of us and a number of chemists [1][2][3][4][5][6][7][8][9][10]. Medicinal properties of benzimidazole derivatives have established that benzimidazoles have privileged substructures for drug design [11,12].…”