Synthesis, Physical Characterization and Biological Evaluation of Schiff BaseCr(III), Mn(III) and Fe(III) Complexes

Abstract

M(III) complexes with Cr, Mn and Fe with Schiff base derived from 2-amino-4-ethyl-5-hydroxy benzaldehyde and oxocarbohydrazide were synthesized and characterized by several techniques using elemental analysis (C, H, N), molar conductance measurements, magnetic measurements, electronic, mass and IR spectral studies. On the bases of these studies, a five coordinated square pyramidal geometry for all these complexes has been proposed and found to be potential antimicrobial agent. The Schiff base ligand and complexes were also tested for their antimicrobial activity (against the bacteriaEscherichia coli, Staphylococcus aureus, Pseudomonas aeruginosaandBacillus megateriumand the fungiKluyveromyces fragilis, Rhodotorula rubra, Candida albicansandTrichoderma reesei) to assess their inhibiting potential. An attempt is also made to correlate the antimicrobial activity with geometry of the complexes. All complexes were found to be less active against the pathogensE.coli, S.aureusandP.aeruginosa. Cr(III) complex showed the best antimicrobial activity, but ligand alone was found to be active against the fungusT.reesei.

Synthesis, Metal Ions Coordination, Antimicrobial Activity of Some L-Tartaric Acid Derivatives

“…The ligands L1, L2 and L3 complexes with trivalent ion Fe(III) and divalent ions Cu(II) and Ni(II) were prepared according to the literature by using appropriate solvents 28 . Ethyl tartarate 2 (L1) dissolved in ethanol while the other ligands, dihydrazide 3 (L2) and bis-oxadiazole 4 (L3) were soluble in water.…”