Synthesis, physical and mechanical properties of amphiphilic hydrogels based on polycaprolactone and polyethylene glycol for bioapplications: A review

Dabbaghi, Alaleh; Ramazani, Ali; Farshchi, Negin; Rezaei, Aram; Bodaghi, Ali; Rezayati, Sobhan

doi:10.1016/j.jiec.2021.05.051

Cited by 34 publications

(17 citation statements)

References 130 publications

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“…Various polyesters with hydrophobic properties serve as hydrophobic blocks, which can form thermosensitive nanomaterials with their complementary hydrophilic PEG. PCL, the most common polyester, has gradually become a research hotspot owing to its high crystallinity, hydrophobicity, biodegradability, and biocompatibility ( Dabbaghi et al, 2021 ). It is a semi-crystalline polymer with a melting temperature (Tm) of 60°C and a glass transition temperature (Tg) of −60°C.…”

Section: Types Of Thermosensitive Nanomaterialsmentioning

confidence: 99%

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Nanomaterials based on thermosensitive polymer in biomedical field

et al. 2022

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The progress of nanotechnology enables us to make use of the special properties of materials on the nanoscale and open up many new fields of biomedical research. Among them, thermosensitive nanomaterials stand out in many biomedical fields because of their “intelligent” behavior in response to temperature changes. However, this article mainly reviews the research progress of thermosensitive nanomaterials, which are popular in biomedical applications in recent years. Here, we simply classify the thermally responsive nanomaterials according to the types of polymers, focusing on the mechanisms of action and their advantages and potential. Finally, we deeply investigate the applications of thermosensitive nanomaterials in drug delivery, tissue engineering, sensing analysis, cell culture, 3D printing, and other fields and probe the current challenges and future development prospects of thermosensitive nanomaterials.

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Section: Types Of Thermosensitive Nanomaterialsmentioning

confidence: 99%

“…Moreover, compared with hydrophilic nanomaterials, they have smaller water swelling and better mechanical properties. Compared with simple nanomaterials, they also have improved thermophysical property, structural stability, and adhesive ability ( Dabbaghi et al, 2021 ).…”

Section: Types Of Thermosensitive Nanomaterialsmentioning

confidence: 99%

Nanomaterials based on thermosensitive polymer in biomedical field

et al. 2022

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“…Some similar studies in gastric cancer reported that chitosan oligosaccharide (COS)-conjugated selenium (Se) and carboxymethyl chitosan (CMCS)-conjugated norcantharidin (NCTD) could remarkably enhance its antitumour efficacy (153)(154)(155)(156). PEG, polylactic acid (PLA), and polycaprolactone (PCL) are FDA-approved commercially available biodegradable copolymers that are widely used to prepare nanoparticles for drug delivery (157). Apatinib (a selective VEGFR-2 inhibitor) and DCT (Taxotere) are widely used for combined treatment in digestive tumours, but their curative effects appear to be impa ired d ue to the disa dvanta ges of th eir p oor pharmacometabolic characteristics (158).…”

Section: Polymeric Nanoparticles and Liposomesmentioning

confidence: 99%

“…PEG, polylactic acid (PLA), and polycaprolactone (PCL) are FDA-approved commercially available biodegradable copolymers that are widely used to prepare nanoparticles for drug delivery ( 157 ). Apatinib (a selective VEGFR-2 inhibitor) and DCT (Taxotere) are widely used for combined treatment in digestive tumours, but their curative effects appear to be impaired due to the disadvantages of their poor pharmacometabolic characteristics ( 158 ).…”

Section: Anti-angiogenic Nanoparticles In Digestive Tumoursmentioning

confidence: 99%

Opportunities and Challenges of Nanoparticles in Digestive Tumours as Anti-Angiogenic Therapies

et al. 2022

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Digestive tumours, a common kind of malignancy worldwide, have recently led to the most tumour-related deaths. Angiogenesis, the process of forming novel blood vessels from pre-existing vessels, is involved in various physiological and pathological processes in the body. Many studies suggest that abnormal angiogenesis plays an important role in the growth, progression, and metastasis of digestive tumours. Therefore, anti-angiogenic therapy is considered a promising target for improving therapeutic efficacy. Traditional strategies such as bevacizumab and regorafenib can target and block the activity of proangiogenic factors to treat digestive tumours. However, due to resistance and some limitations, such as poor pharmacokinetics, their efficacy is not always satisfactory. In recent years, nanotechnology-based anti-angiogenic therapies have emerged as a new way to treat digestive tumours. Compared with commonly used drugs, nanoparticles show great potential in tumour targeted delivery, controlled drug release, prolonged cycle time, and increased drug bioavailability. Therefore, anti-angiogenic nanoparticles may be an effective complementary therapy to treat digestive tumours. In this review, we outline the different mechanisms of angiogenesis, the effects of nanoparticles on angiogenesis, and their biomedical applications in various kinds of digestive tumours. In addition, the opportunities and challenges are briefly discussed.

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“…Indeed, the appropriate formulation can be used to activate the drug release from thermosensitive hydrogels. Poly(ε-caprolactone) (PCL) is another polymer used for hydrogel formulation, thanks to its biodegradability and biocompatibility; it is approved by the FDA for application in health care [67]. When it is copolymerized with PEG, it is possible to obtain a thermosensitive copolymer (PCL-PEG) able to perform a solgel transition by increasing the temperature in a range between ambient temperature and 37°C [68,69].…”

Section: Article Highlightsmentioning

confidence: 99%

Polymer-based thermoresponsive hydrogels for controlled drug delivery

Lacroce

Rossi

2022

Expert Opinion on Drug Delivery

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Introduction: Controlled drug delivery through hydrogels is generally limited by the poor barrier that polymeric network can create to diffusion mechanism. Stimuli responsive polymers can help in this way guaranteeing that delivery can be sustained and finely controlled using an external stimulus. Area covered: This review provides an overview of recent studies about the use of temperature as an external stimulus able to work as an efficient new route of drug's administration. Thermoresponsive hydrogels are discussed and compared in terms of physical properties and mechanism of drug release considering their classification in intrinsical (formed by thermosensitive polymers) and non-intrinsical (polymers with thermosensitive moieties) hydrogels. Expert opinion: Thermoresponsive hydrogels can be developed by using different polymers added or not with micro/nanoparticles of organic or inorganic origin. In both cases, the final system represents an innovative way for the local and sustained drug delivery in a specific site of the body. In particular, it is possible to obtain an on-demand release of drug by applying a local increase of temperature to the system.

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Synthesis, physical and mechanical properties of amphiphilic hydrogels based on polycaprolactone and polyethylene glycol for bioapplications: A review

Cited by 34 publications

References 130 publications

Nanomaterials based on thermosensitive polymer in biomedical field

Nanomaterials based on thermosensitive polymer in biomedical field

Opportunities and Challenges of Nanoparticles in Digestive Tumours as Anti-Angiogenic Therapies

Polymer-based thermoresponsive hydrogels for controlled drug delivery

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