2006
DOI: 10.1002/jlcr.1099
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Synthesis of18F-labelled biphenyls via SUZUKI cross-coupling with 4-[18F]fluoroiodobenzene

Abstract: SummaryThe The reaction proceeded in excellent radiochemical yields of up to 94% within 5 min while showing good compatibility to many functional groups.

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Cited by 18 publications
(12 citation statements)
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“…Removal of the excess diiodobenzene byproduct can be achieved by automated solid-phase extraction. [225] The Suzuki reaction has been investigated as a method to couple together simple [ 18 F]fluoroaryl derivatives to form a series of [ 18 F]fluorobiphenyls (Scheme 49). [225] The reaction of 75 with p-tolylboronic acid was used as a model reaction to screen the effectiveness of different palladium complexes, bases, and solvents.…”
Section: Synthesis Of Pet Labelsmentioning
confidence: 99%
See 1 more Smart Citation
“…Removal of the excess diiodobenzene byproduct can be achieved by automated solid-phase extraction. [225] The Suzuki reaction has been investigated as a method to couple together simple [ 18 F]fluoroaryl derivatives to form a series of [ 18 F]fluorobiphenyls (Scheme 49). [225] The reaction of 75 with p-tolylboronic acid was used as a model reaction to screen the effectiveness of different palladium complexes, bases, and solvents.…”
Section: Synthesis Of Pet Labelsmentioning
confidence: 99%
“…[225] The Suzuki reaction has been investigated as a method to couple together simple [ 18 F]fluoroaryl derivatives to form a series of [ 18 F]fluorobiphenyls (Scheme 49). [225] The reaction of 75 with p-tolylboronic acid was used as a model reaction to screen the effectiveness of different palladium complexes, bases, and solvents. The optimum coupling conditions to give the highest RCYs were found to be [Pd 2 -(dba) 3 ], Cs 2 CO 3 , and acetonitrile at 60 8C for 5 minutes.…”
Section: Synthesis Of Pet Labelsmentioning
confidence: 99%
“…There are only a few examples of biphenolic compounds labeled with PET isotopes and no information is available on the synthesis of potential PET radiotracers based on MH structure. Thus, the aim of this study was to prepare [ 11 C]‐labeled MH derivative (4′‐[ 11 C]methoxy‐5‐propyl‐1,1′‐biphenyl‐2‐ol or [ 11 C]MPbP) and ex vivo evaluate it on a rat model of LPS neuroinflammation.…”
Section: Figurementioning
confidence: 99%
“…Steiniger and Wuest coupled 4-[ 18 F]fluoroiodobenzene and 4-tolylboronic acid 50 with a variety of Pd(0) and Pd(II) catalysts, bases, and solvent conditions (Scheme 27b) [202]. They determined that Pd 2 (dba) 3 with Cs 2 CO 3 in MeCN were the ideal conditions to further investigate the cross-coupling of 4-[ 18 F]fluoroiodobenzene with various aryl boronic acids.…”
Section: Other Strategies For Radiolabeling With Fluorine-18mentioning
confidence: 99%