Synthesis of α-ribonucleoside (Majority) by the Coupling of NP/KI and NP/I₂

Abstract

In this work we will demonstrate a method of preparing α-D-ribonucleosides using the solid-phase approach using the combination between natural phosphate doped with potassium iodide (NP/KI) and natural phosphate doped with iodine (NP/I2). All these derivatives ribonucleosides were prepared by N-glycosylation reaction between silylated bases and 1-O-acétyl-2,3,5-tri-O-benzoyl-β-D-ribofuranoside.