Synthesis of Zn-MOF incorporating titanium-hydrides as active sites binding H2 molecules

Kim, Jongsik; Kim, Dong Ok; Kim, Dong Wook; Sagong, Kil

doi:10.1016/j.jssc.2015.06.034

Cited by 5 publications

(2 citation statements)

References 47 publications

(145 reference statements)

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“…The large number of combinations of metal ions and organic ligands available during such material synthesis confers a high degree of tunability of MOF's geometry, size, porosity and functionality, respectively 5,6. Such features conversely elicit MOF integration in numerous applications ranging from gas capture and storage7,8 to water adsorption and from catalysis to electrical-based applications 9–12…”

Section: Introductionmentioning

confidence: 99%

<p>Toxicity screening of two prevalent metal organic frameworks for therapeutic use in human lung epithelial cells</p>

Wagner

Liu

Rose

et al. 2019

IJN

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IntroductionThe flexibility and tunability of metal organic frameworks (MOFs), crystalline porous materials composed of a network of metal ions coordinated by organic ligands, confer their variety of applications as drug delivery systems or as sensing and imaging agents. However, such properties also add to the difficulty in ensuring their safe implementation when interaction with biological systems is considered.MethodsIn the current study, we used real-time sensorial strategies and cellular-based approaches to allow for fast and effective screening of two MOFs of prevalent use, namely, MIL-160 representative of a hydrophilic and ZIF-8 representative of a hydrophobic framework. The two MOFs were synthesized “in house” and exposed to human bronchial epithelial (BEAS-2B) cells, a pertinent toxicological screening model.ResultsAnalysis allowed evaluation and differentiation of particle-induced cellular effects as well identification of different degrees and routes of toxicity, all in a high-throughput manner. Our results show the importance of performing screening toxicity assessments before introducing MOFs to biomedical applications.DiscussionOur proposed screening assays could be extended to a wider variety of cell lines to allow for identification of any deleterious effects of MOFs, with the range of toxic mechanisms to be differentiated based on cell viability, morphology and cell–substrate interactions, respectively.ConclusionOur analysis highlights the importance of considering the physicochemical properties of MOFs when recommending a MOF-based therapeutic option or MOFs implementation in biomedical applications.

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Section: Introductionmentioning

confidence: 99%

<p>Toxicity screening of two prevalent metal organic frameworks for therapeutic use in human lung epithelial cells</p>

Wagner

Liu

Rose

et al. 2019

IJN

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“…转而他们选用较小分子体积的 Ti(O i Pr) 4 修饰 IRMOF-3, 进一步碳热还原得到金属氧化物纳米颗粒, 用于催化二苯并噻吩(DBT)氧化 [69] 和木质纤维素生物质转化 [70] . 此外, 不同钛源配体修饰构筑的 Ti-MOFs 可直接用于环己烯催化转化 [71] 、H 2 吸附 [72] 、醛及酮氢硼化 [73] 等. [63] .…”

Section: 离子插入unclassified

A Post-Synthetic Method for the Construction of Titanium-Based Metal Organic Frameworks and Their Applications

Xueping,

Fei,

Jian

2023

Acta Chimica Sinica

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Titanium-based metal organic frameworks (Ti-MOFs) have become a hot topic in current materials research due to their excellent photocatalytic activity. However, due to the extremely high reactivity and oxygenophilic properties of Ti ions, oxides and other competing by-products are easily formed during the reaction process, making the synthesis of Ti-MOFs extremely challenging. The research on Ti-MOFs was carried out simultaneously at the early stage of MOFs development, however, after more than two decades of development, only tens of Ti-MOFs have been reported, accounting for an extremely limited proportion of the tens of thousands of MOFs. In order to avoid or reduce the occurrence of titanium ion side reactions, Ti-MOFs are usually synthesized by introducing metal Ti ions into the framework of known MOFs to orientate the synthesis of Ti-MOFs, which is called post-synthetic method (PSM) and is also an effective method to construct Ti-MOF framework. The examples of PSM for constructing Ti-MOFs are systematically investigated and summarized in a timely manner. Firstly, based on the different ways and positions of titanium ion introduction, three routes are classified as ion exchange, ion insertion (introduction of titanium ion at the position of metal nodes or cluster units) and ligand modification (introduction of titanium ion at the position of organic ligands), and the Ti-MOFs constructed by each route are introduced by examples. Subsequently, the design and application of Ti-MOFs constructed by PSM and their composites are discussed. Finally, the current status of PSM-constructed Ti-MOFs is summarized and the future development direction is foreseen. Keywords metal organic framework; post-synthetic method (PSM); titanium; photocatalysis 1 引言金属有机框架(MOFs)是由金属离子/簇单元通过有机配体连接形成的一类晶态多孔材料, 具有超高的孔隙率/比表面积、孔尺寸和孔环境高度可调节及结构可设计和可预测性强等优点. 在吸附分离 [1][2][3] 、催化 [4][5][6] 、电子传输 [7] 和抗菌 [8] 等诸多方面具有潜在的应用前景. 其中, 钛离子具有光活性、低毒性及丰富储量, 使得钛基金属有机框架(Ti-MOFs)成为 MOFs 的一个重要分支和当前研究的热点领域之一 [9][10][11][12] .

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Tuning the Properties of Metal–Organic Frameworks by Post‐synthetic Modification

Burrows

Cadman

Gee

et al. 2018

Metal‐Organic Frameworks

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Synthesis of Zn-MOF incorporating titanium-hydrides as active sites binding H2 molecules

Cited by 5 publications

References 47 publications

<p>Toxicity screening of two prevalent metal organic frameworks for therapeutic use in human lung epithelial cells</p>

<p>Toxicity screening of two prevalent metal organic frameworks for therapeutic use in human lung epithelial cells</p>

A Post-Synthetic Method for the Construction of Titanium-Based Metal Organic Frameworks and Their Applications

Tuning the Properties of Metal–Organic Frameworks by Post‐synthetic Modification

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