Synthesis of xanthone derivatives based on α-mangostin and their biological evaluation for anti-cancer agents

Anti-Bacterial and Anti-Fungal Activity of Xanthones Obtained via Semi-Synthetic Modification of α-Mangostin from Garcinia mangostana

“…Since α- and non-α-mangostin xanthones have been shown to possess anti-bacterial activity, especially against Gram-positive bacteria [ 12 , 13 , 14 , 15 , 16 , 17 , 18 ], it is most probable that semi-synthetic analogs would be produced with enhanced anti-bacterial activity. In order to increase the bioactivity and antibacterial properties of α-mangostin, semi-synthetic modification of the compound was performed by several authors, to lead to more active compounds [ 25 , 26 , 27 , 28 , 29 ], with no excessive toxicity. Alongside their anti-microbial properties, the synthetic analogs possess wound healing and anti-inflammatory activity and, hence, they could be exploited in the treatment of skin infections.…”

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“…There have been some preliminary studies that attempted to improve its bioavailability. For instance, Fei et al [137] synthesized several α-MG analogs through substitution of the hydroxyl groups at C1, C3, and C6, cyclization at C-2 and C-3, and modification at C4 and at C7 with the aim of improving its antitumor activity and water solubility. Despite showing an improved water solubility, all of them reduced the activity of the parent compound.…”

Synthesis, Characterization and Antimicrobial Properties of Copper(ii) Complex of Heterocyclic Ligands

“…The newly synthesized compound will be tested for antimicrobial properties. Isolated -mangostin was inactive against antimicrobial [9] and anticancer [10]. The inclusion of copper(II) could alter the overall structure of newly formed synthesized compound and thus can increase the biological properties of the compound.…”