Synthesis of whitlockite nanopowders with different magnesium content

Dissolution–precipitation synthesis and thermal stability of magnesium whitlockite

“…15–17 Depending on the specific purpose in regenerative medicine, CPs can be used in different forms. To the best of our knowledge, to date Mg-WH has already been prepared in the form of powders, 16 granules, 18 coating on TCP ceramics 19 and different composites; 10,20,21 however, there are no data on the fabrication of ceramics. Conventional ceramic routes consider sintering at high temperature, which is needed for the densification of materials.…”

“…13,14 It was assumed for a long time that synthesis of phasepure Mg-WH is a challenging task due to the formation of other CPs; however, in recent years this issue was overcame and different successful synthetic approaches were demonstrated. [15][16][17] Depending on the specific purpose in regenerative medicine, CPs can be used in different forms. To the best of our knowledge, to date Mg-WH has already been prepared in the form of powders, 16 granules, 18 coating on TCP ceramics 19 and different composites; 10,20,21 however, there are no data on the fabrication of ceramics.…”

Large-Scale Green Synthesis of Magnesium Whitlockite from Environmentally Benign Precursor

“…The EDX of the elemental analysis results showed the presence of calcium (Ca), magnesium (Mg), phosphorus (P), and oxygen (O) in the Mg-WH sample (see Figure 7). Quantitative analysis yielded atomic concentrations of Ca:Mg [38], the inherent flexibility of the Mg-WH structure allows for variation in the calcium-to-magnesium ratio. Consequently, our synthesized sample exhibited a slightly reduced magnesium content compared to that of the stoichiometric Mg-WH, reflecting the adaptability of the Mg-WH structure to accommodate subtle compositional variations.…”

“…Quantitative analysis yielded atomic concentrations of Ca:Mg:P:O as 21.44:1.53:15.61:61.42 in the Mg-WH sample, closely aligned with the atomic concentration values for stoichiometric Mg-WH (Ca 18 Mg 2 (HPO 4 ) 2 (PO 4 ) 12 ), which are 20.00:2.22:15.55:62.22. As suggested in [38], the inherent flexibility of the Mg-WH structure allows for variation in the calciumto-magnesium ratio. Consequently, our synthesized sample exhibited a slightly reduced magnesium content compared to that of the stoichiometric Mg-WH, reflecting the adaptability of the Mg-WH structure to accommodate subtle compositional variations.…”

Enhanced bone regeneration by osteoinductive and angiogenic zein/whitlockite composite scaffolds loaded with levofloxacin

“… 10 The formation process involves partially substituting calcium ions within the crystal lattice of calcium orthophosphate with magnesium ions. 11 The content of whitlockite is higher than that of hydroxyapatite (HAP) in the early stage of biological mineralization. It is involved in the initial phase of bone regeneration by stimulating osteogenic differentiation and inhibiting osteoclast activity.…”