Synthesis of Well‐Dispersed Aqueous‐Phase Magnetite Nanoparticles and Their Metabolism as an MRI Contrast Agent for the Reticuloendothelial System

Abstract

Aqueous-phase Fe 3 O 4 nanoparticles (NPs), with a size of 9.8 Ϯ 3.0 nm, are directly synthesized by a modified iron salt coprecipitation process, stabilized by the synergistic effect of a combination of poly(vinylpyrrolidone) (PVP), trisodium citrate (TSC), and maleic anhydride (MAH). These NPs show good aqueous-phase dispersion stability and excellent superparamagnetic properties with a saturation magnetization of 48.0 emu/g at a low magnetic field of 0.5 T. Their biocompatibility and metabolism for application in magnetic resonance reticuloendothelial system examinations are investigated by

Preparation of polylysine-modified superparamagnetic iron oxide nanoparticles

“…2b, and the calculated amount of PLL connected with PEG-SPIONs are about 4.4 wt%. The TGA curves still show weight loss at temperatures around 600 1C and similar results can be found in other works [15,16]. This most probably is caused by the interaction between the polymers and the nanoparticles, which increases the decomposition temperature of the polymers.…”

Superparamagnetic Iron Oxide Nanoparticles (SPIONs): Synthesis and Surface Modification Techniques for use with MRI and Other Biomedical Applications

“…The primary reason for this method's popularity is its mild and simple synthesis procedure, typically carried out in aqueous media under ambient conditions [14,15]. Furthermore, it is an extremely inexpensive, scalable and high-yield method that can produce roughly size-controlled nanoparticles with hydrophilic surface properties from relatively non-toxic reagents [16][17][18]. However, the shape, size and size distribution of the particles can vary from batch to batch among different laboratories, and are strongly dependent on a large number of procedural parameters, including pH, the concentration and ratio of reactants, ionic strength and temperature of the reaction mixture [5,16].…”

Magneto-Plasmons in Periodic Nanoporous Structures

“…Nanospheres (NSs) with size dispersion below 4% can self-assemble into a uniform monolayer on a large scale (exceeding 5 mm 3 5 mm) using a modified drop-coating process 22,29,42 . Figure 1A shows a typical SEM image of the monolayer nanosphere template with a nanosphere diameter of 970 6 19 nm.…”

“…This innovative approach also offers a route for overcoming undesirable compromises between material properties and performance that accompany size reduction in nanotechnology. Examples include increased activity but reduced stability [5][6][7][14][15][16][17][18] , superparamagnetism versus ferromagnetism 3,19 , increased sensitivity but reduced intensity 11,[20][21][22] , and enhanced magneto-optical effect but increased energy loss 23,24 . Applications of new types of multi-functional nanoparticles (NPs) based on hybridization require control over the mismatch among different components and a good understanding of the interface-coupling and proximity effects in the constituent parts 3,5,7,8,25 .…”