Synthesis of well-defined poly(N-isopropylacrylamide)-b-poly(L-glutamic acid) by a versatile approach and micellization

Deng, Lin; Shi, Kun; Zhang, Yuying; Wang, Haimei; Zeng, Jianguo; Guo, Xu; Du, Zongjie; Zhang, Baolong

doi:10.1016/j.jcis.2008.04.007

Cited by 29 publications

(17 citation statements)

References 32 publications

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“…It exhibits a sharp coil‐to‐globule transition at its low critical solution temperature (LCST) of around 32°C 18. Poly( N ‐isopropylacylamide)‐ b ‐PLGlu (PNIPAM‐ b ‐PLGlu, Scheme f) diblock copolymers have been synthesized via ROP of BLG‐NCA by using monoanimo‐terminated PNIPAM as a macroinitiator, followed by deprotection of the BLG groups 113–116. In order to obtain well‐defined PNIPAM–polypeptide diblock copolymers, PNIPAM was synthesized via controlled radical polymerization,115–117 and ammonium chloride‐functionalized PNIPAM was used as macroinitiators for ROP of NCAs 113, 118.…”

Section: Stimuli‐sensitive Polypeptide‐based Materialsmentioning

confidence: 99%

Stimuli‐Sensitive Synthetic Polypeptide‐Based Materials for Drug and Gene Delivery

Zhuang

Tang

et al. 2011

Adv Healthcare Materials

314

217

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Stimuli‐sensitive synthetic polypeptides are unique biodegradable and biocompatible synthetic polymers with structures mimicking natural proteins. These polymers exhibit reversible secondary conformation transitions and/or hydrophilic–hydrophobic transitions in response to changes in environmental conditions such as pH and temperature. The stimuli‐triggered conformation and/or phase transitions lead to unique self‐assembly behaviors, making these materials interesting for controlled drug and gene delivery applications. Therefore, stimuli‐sensitive synthetic polypeptide‐based materials have been extensively investigatid in recent years. Various polypeptide‐based materials, including micelles, vesicles, nanogels, and hydrogels, have been developed and tested for drug‐ and gene‐delivery applications. In addition, the presence of reactive side groups in some polypeptides facilitates the incorporation of various functional moieties to the polypeptides. This Review focuses on recent advances in stimuli‐sensitive polypeptide‐based materials that have been designed and evaluated for drug and gene delivery applications. In addition, recent developments in the preparation of stimuli‐sensitive functionalized polypeptides are discussed.

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Section: Stimuli‐sensitive Polypeptide‐based Materialsmentioning

confidence: 99%

Stimuli‐Sensitive Synthetic Polypeptide‐Based Materials for Drug and Gene Delivery

Zhuang

Tang

et al. 2011

Adv Healthcare Materials

314

217

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“…Size of assemblies is typically 10–100 nm and can be precisely controlled by varying the structure of the amphiphilic macromolecules by the choice of the length of the hydrophobic fragments. A number of recent studies have discussed feasibility of polymeric micellar assemblies as carriers for various biomedical applications, including vaccine adjuvants (substances that are incorporated with a vaccine and enhance an immune response) . Amphiphilic macromolecules provide an ability to tailor adjuvant properties by varying the macromolecular structure and facilitating the delivery of specific antigens .…”

Section: Introductionmentioning

confidence: 99%

¹H NMR Study of “Host–Guest” Interactions of Micellar Assemblies from Amphiphilic Invertible Polymers and Peptides

Kohut¹,

Жолобко

Hevus

et al. 2017

Macro Chemistry & Physics

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“Host–guest” interactions between self‐assembled micellar nanostructures from amphiphilic invertible polymers (AIPs) and two peptides, swine‐origin Influenza A surface protein Hemagglutinin and research antibody peptide V5, are investigated by changing the polymer concentration and polymer/peptide ratio in the aqueous solution. Formation of mixed micellar assemblies from AIP and each peptide is revealed using detailed 1H NMR spectroscopic study. Peptide molecule localization in the micellar assemblies depends on the specific interactions between amino acid functional groups of the peptide and polymer fragments. The resulting mixed micellar structures can be considered as a promising material toward delivery and stimuli‐responsive sustained release of peptides.

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“…Applications containing guest molecules as stimuli‐sensitive systems include drug delivery systems, cell culture, cell harvesting, functional biomaterials, biosensors, etc. Because of the dilution effect, practical applications are limited, especially as the polymer concentration drops below the critical micelle concentration, decomposing the micelles into single units . To increase stability of the supramolecular nanostructure obtained by polymeric micelles, many methods have been developed for forming cross‐linked micelles.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of temperature‐ and pH‐responsive diblock copolymers and their silica‐coated nanoparticles

Yang

et al. 2018

Polymers for Advanced Techs

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Multiresponsive amphiphilic poly(N,N-dimethylaminoethyl methacrylate)-b-poly(Nisopropylacrylamide) (PDMAEMA-b-PNIPAM) was successfully synthesized by reversible addition-fragmentation chain transfer polymerization. Poly(N,Ndimethylaminoethyl methacrylate)-b-poly(N-isopropylacrylamide) has thermal and pH stimuli responsiveness. Their lower critical solution temperature and hydrodynamic radius can be adjusted by varying the copolymer composition, block length, solution pH, and temperature. In addition, a convenient method has been established to prepare cross-linked silica-coated nanoparticles with PDMAEMA-b-PNIPAM micelles as a template, resulting in good organic/inorganic hybrid nanoparticles defined as 175 to 220 nm. The structure and morphology were characterized by proton nuclear magnetic resonance ( 1 HNMR), Fourier-transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM), and transmission electron microscopy-energy dispersive X-ray spectroscopy (TEM-EDS).

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Synthesis of well-defined poly(N-isopropylacrylamide)-b-poly(L-glutamic acid) by a versatile approach and micellization

Cited by 29 publications

References 32 publications

Stimuli‐Sensitive Synthetic Polypeptide‐Based Materials for Drug and Gene Delivery

Stimuli‐Sensitive Synthetic Polypeptide‐Based Materials for Drug and Gene Delivery

¹H NMR Study of “Host–Guest” Interactions of Micellar Assemblies from Amphiphilic Invertible Polymers and Peptides

Preparation and characterization of temperature‐ and pH‐responsive diblock copolymers and their silica‐coated nanoparticles

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Synthesis of well-defined poly(N-isopropylacrylamide)-b-poly(L-glutamic acid) by a versatile approach and micellization

Cited by 29 publications

References 32 publications

Stimuli‐Sensitive Synthetic Polypeptide‐Based Materials for Drug and Gene Delivery

Stimuli‐Sensitive Synthetic Polypeptide‐Based Materials for Drug and Gene Delivery

1H NMR Study of “Host–Guest” Interactions of Micellar Assemblies from Amphiphilic Invertible Polymers and Peptides

Preparation and characterization of temperature‐ and pH‐responsive diblock copolymers and their silica‐coated nanoparticles

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¹H NMR Study of “Host–Guest” Interactions of Micellar Assemblies from Amphiphilic Invertible Polymers and Peptides