Synthesis of water-soluble gold clusters in nanosomes displaying robust photoluminescence with very large Stokes shift

González, Beatriz Santiago; Vázquez–Vázquez, C.; Blanco, M. Carmen; Martinho, J. M. G.; Ramallo‐López, José M.; Requejo, Félix G.; López‐Quintela, M. Arturo

doi:10.1016/j.jcis.2015.05.042

Cited by 17 publications

(9 citation statements)

References 43 publications

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“…Ultrasmall metal nanoclusters exhibit many unique properties such as luminescence, catalytic activity, and magnetism (see, e.g., , , − , , , , , and ). Among these properties, the luminescence properties of nanoclusters of gold (see refs , , , , , and − ), silver, − copper, − and bimetals − have received enormous interest. Most such nanoclusters are typically prepared by methods such as templating, etching, microwave-facilitated synthesis, and ligand or surfactant control. ,,− Silver nanoclusters are often more luminescent than gold ones. , Luminescent nanoclusters have found tremendous applications in nanomedicine, − such as bioassays of DNA/protein, , immunorecognition and pharmacokinetics, biolabeling and cellular imaging, − chiral recognition, dual-modal fluorescence/X-ray computed tomography imaging, drug delivery, cancer therapy, …”

Section: Applicationsmentioning

confidence: 99%

“…Metal nanoclusters have a number of advantages as imaging probes (e.g., see refs − , , , , , and ), such as ultrasmall size, ,, color tunability (refs , , , , and ), NIR luminescence (>700 nm), ,, long lifetime (from 10 2 ns to μs) (refs , , , and ), high photostability, low cytotoxicity, , and large Stokes shift. , When coupled with the deep penetration distance and high resolution of two-photon imaging techniques, metal nanoclusters offer some unique opportunities compared to the visible, one-photon imaging techniques.…”

Section: Applicationsmentioning

confidence: 99%

“…In addition, the TPF signals exhibit high stability in water (e.g., nearly constant during continuous irradiation with femtosecond laser pulses with a power of 230 mW for 1 h) 232 The TPA cross section was further measured to be ∼1.9 × 10 5 GM, much higher than those of typical dyes and quantum dots. Metal nanoclusters have a number of advantages as imaging probes (e.g., see refs 458−460, 473, 494, 498, 513, and 524), such as ultrasmall size, 476,477,520 color tunability (refs 491, 493, 516, 520, and 528), NIR luminescence (>700 nm), 239,453,491 long lifetime (from 10 2 ns to μs) (refs 518, 520, 531, and 598), high photostability, 455 low cytotoxicity, 494,513 and large Stokes shift. 455,459 When coupled with the deep penetration distance and high resolution of two-photon imaging techniques, metal nanoclusters offer some unique opportunities compared to the visible, one-photon imaging techniques.…”

Section: Optical Imagingmentioning

confidence: 99%

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Atomically Precise Colloidal Metal Nanoclusters and Nanoparticles: Fundamentals and Opportunities

et al. 2016

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Colloidal nanoparticles are being intensely pursued in current nanoscience research. Nanochemists are often frustrated by the well-known fact that no two nanoparticles are the same, which precludes the deep understanding of many fundamental properties of colloidal nanoparticles in which the total structures (core plus surface) must be known. Therefore, controlling nanoparticles with atomic precision and solving their total structures have long been major dreams for nanochemists. Recently, these goals are partially fulfilled in the case of gold nanoparticles, at least in the ultrasmall size regime (1-3 nm in diameter, often called nanoclusters). This review summarizes the major progress in the field, including the principles that permit atomically precise synthesis, new types of atomic structures, and unique physical and chemical properties of atomically precise nanoparticles, as well as exciting opportunities for nanochemists to understand very fundamental science of colloidal nanoparticles (such as the stability, metal-ligand interfacial bonding, ligand assembly on particle surfaces, aesthetic structural patterns, periodicities, and emergence of the metallic state) and to develop a range of potential applications such as in catalysis, biomedicine, sensing, imaging, optics, and energy conversion. Although most of the research activity currently focuses on thiolate-protected gold nanoclusters, important progress has also been achieved in other ligand-protected gold, silver, and bimetal (or alloy) nanoclusters. All of these types of unique nanoparticles will bring unprecedented opportunities, not only in understanding the fundamental questions of nanoparticles but also in opening up new horizons for scientific studies of nanoparticles.

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Section: Applicationsmentioning

confidence: 99%

Section: Applicationsmentioning

confidence: 99%

Section: Optical Imagingmentioning

confidence: 99%

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Atomically Precise Colloidal Metal Nanoclusters and Nanoparticles: Fundamentals and Opportunities

et al. 2016

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“…1a, which is based on the chemical reduction of the Ag precursor (AgNO 3 ) in the presence of HAuCl 4 (nominal Ag:Au ratio 1:2), mercapto-palmitic acids and tetrabutyl ammonium salts 48–50 . As control materials, we fabricated monometallic clusters by adopting the same reaction conditions as the synthesis of the Ag/Au-t systems, but introducing exclusively Ag or Au precursors in the reaction medium.…”

Section: Resultsmentioning

confidence: 99%

Metal Nanoclusters with Synergistically Engineered Optical and Buffering Activity of Intracellular Reactive Oxygen Species by Compositional and Supramolecular Design

González

Monguzzi

Caputo

et al. 2017

Sci Rep

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Metal nanoclusters featuring tunable luminescence and high biocompatibility are receiving attention as fluorescent markers for cellular imaging. The recently discovered ability of gold clusters to scavenge cytotoxic reactive oxygen species (ROS) from the intracellular environment extends their applicability to biomedical theranostics and provides a novel platform for realizing multifunctional luminescent probes with engineered anti-cytotoxic activity for applications in bio-diagnostics and conceivably cellular therapy. This goal could be achieved by using clusters of strongly reactive metals such as silver, provided that strategies are found to enhance their luminescence while simultaneously enabling direct interaction between the metal atoms and the chemical surroundings. In this work, we demonstrate a synergic approach for realizing multifunctional metal clusters combining enhanced luminescence with strong and lasting ROS scavenging activity, based on the fabrication and in situ protection of Ag nanoclusters with a supramolecular mantle of thiolated-Au atoms (Ag/Au-t). Confocal imaging and viability measurements highlight the biocompatibility of Ag/Au-t and their suitability as fluorescent bio-markers. ROS concentration tests reveal the remarkable scavenging activity of Ag-based clusters. Proliferation tests of cells in artificially stressed culture conditions point out their prolonged anti-cytotoxic effect with respect to gold systems, ensuring positive cell proliferation rates even for long incubation time.

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“…79 Au NCs also present large Stokes shift in comparison to most of the organic fluorophores (o20-30 nm 80 ), which can exceed 100 nm. 81,82 This reduces the scattering and absorption of light and improves fluorescence detection.…”

Section: Synthesis Parametersmentioning

confidence: 99%

Gold nanoclusters for biomedical applications: toward in vivo studies

2020

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Synthesis of water-soluble gold clusters in nanosomes displaying robust photoluminescence with very large Stokes shift

Cited by 17 publications

References 43 publications

Atomically Precise Colloidal Metal Nanoclusters and Nanoparticles: Fundamentals and Opportunities

Atomically Precise Colloidal Metal Nanoclusters and Nanoparticles: Fundamentals and Opportunities

Metal Nanoclusters with Synergistically Engineered Optical and Buffering Activity of Intracellular Reactive Oxygen Species by Compositional and Supramolecular Design

Gold nanoclusters for biomedical applications: toward in vivo studies

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