Synthesis of ultrastable and multifunctional gold nanoclusters with enhanced fluorescence and potential anticancer drug delivery application

Zhang, Xiaodong; Wu, Fu‐Gen; Liu, Peidang; Wang, Hongyin; Gu, Ning; Chen, Zhan

doi:10.1016/j.jcis.2015.05.029

Cited by 27 publications

(24 citation statements)

References 68 publications

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“…In recent decades, intensive research has been undertaken to develop new synthesis leading to ultrastable GNP. An exhaustive review of highly-stable and ultrastable GNPs led to only a dozen publications describing new synthesis conditions and resistance against different criteria [11,12,13,14,15,16,17,18,19,20,21,22]. However, most of the time, GNPs presented ultrastable properties only under limited conditions and were not water-soluble.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Ultrastable Gold Nanoparticles as a New Drug Delivery System

et al. 2019

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Nanotechnologies are increasingly being developed for medical purposes. However, these nanomaterials require ultrastability for better control of their pharmacokinetics. The present study describes three types of ultrastable gold nanoparticles stabilized by thiolated polyethylene glycol groups remaining intact when subjected to some of the harshest conditions described thus far in the literature, such as autoclave sterilization, heat and freeze-drying cycles, salts exposure, and ultracentrifugation. Their stability is characterized by transmission electron microscopy, UV-visible spectroscopy, and dynamic light scattering. For comparison purposes, two conventional nanoparticle types were used to assess their colloidal stability under all conditions. The ability of ultrastable gold nanoparticles to encapsulate bimatoprost, a drug for glaucoma treatment, is demonstrated. MTS assays on human corneal epithelial cells is assessed without changing cell viability. The impact of ultrastable gold nanoparticles on wound healing dynamics is assessed on tissue engineered corneas. These results highlight the potential of ultrastable gold nanoparticles as a drug delivery system in ocular therapy.

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Section: Introductionmentioning

confidence: 99%

Synthesis of Ultrastable Gold Nanoparticles as a New Drug Delivery System

et al. 2019

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“…3,8,9 Therefore, they are widely applied in imaging, drug deliveries, and cancer radiation therapies. [1][2][3][9][10][11][12][13][14][15][16][17] As a preclinical molecule, potential toxicities could hinder further medical applications. In contrast to small chemical molecules, nanosized particles with larger volumetric specific surface area are more reactive.…”

Section: Introductionmentioning

confidence: 99%

Effects of surface charges of gold nanoclusters on long-term in vivo biodistribution, toxicity, and cancer radiation therapy

Wang

Chen

Yang

et al. 2016

IJN

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Gold nanoclusters (Au NCs) have exhibited great advantages in medical diagnostics and therapies due to their efficient renal clearance and high tumor uptake. The in vivo effects of the surface chemistry of Au NCs are important for the development of both nanobiological interfaces and potential clinical contrast reagents, but these properties are yet to be fully investigated. In this study, we prepared glutathione-protected Au NCs of a similar hydrodynamic size but with three different surface charges: positive, negative, and neutral. Their in vivo biodistribution, excretion, and toxicity were investigated over a 90-day period, and tumor uptake and potential application to radiation therapy were also evaluated. The results showed that the surface charge greatly influenced pharmacokinetics, particularly renal excretion and accumulation in kidney, liver, spleen, and testis. Negatively charged Au NCs displayed lower excretion and increased tumor uptake, indicating a potential for NC-based therapeutics, whereas positively charged clusters caused transient side effects on the peripheral blood system.

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“…[65] Interestingly, few reports have recently described the unique nuclei staining properties of AuNCs, [66,67] which could allow the study of important biological processes such as mitosis. [67] This nuclei targeting is also the origin of several drug delivery studies, [68][69][70][71] such as DOX delivery via AuNC@BSA combined with two-photon imaging. [72] AuNCs were also covalently grafted on non-porous silica NPs for cytosol imaging and reactive oxygen species detection via the quenching of the gold fluorescence, [73] however, AuNCs were not combined with MSN.…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

Protein-gold clusters-capped mesoporous silica nanoparticles for high drug loading, autonomous gemcitabine/doxorubicin co-delivery, and in-vivo tumor imaging

Croissant¹,

Zhang

Alsaiari

et al. 2016

Journal of Controlled Release

151

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, Protein-gold clusters-capped mesoporous silica nanoparticles for high drug loading, autonomous gemcitabine/doxorubicin co-delivery, and in-vivo tumor imaging, Journal of Controlled Release (2016Release ( ), doi: 10.1016Release ( /j.jconrel.2016 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT

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Synthesis of ultrastable and multifunctional gold nanoclusters with enhanced fluorescence and potential anticancer drug delivery application

Cited by 27 publications

References 68 publications

Synthesis of Ultrastable Gold Nanoparticles as a New Drug Delivery System

Synthesis of Ultrastable Gold Nanoparticles as a New Drug Delivery System

Effects of surface charges of gold nanoclusters on long-term in vivo biodistribution, toxicity, and cancer radiation therapy

Protein-gold clusters-capped mesoporous silica nanoparticles for high drug loading, autonomous gemcitabine/doxorubicin co-delivery, and in-vivo tumor imaging

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