Synthesis of tumor-targeted folate conjugated fluorescent magnetic albumin nanoparticles for enhanced intracellular dual-modal imaging into human brain tumor cells

Wang, Xueqin; Tu, Miaomiao; Tian, Bin; Yi, Yanjie; Wei, Zhenzhen; Wei, Fang

doi:10.1016/j.ab.2016.08.010

Cited by 50 publications

(24 citation statements)

References 46 publications

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“…It has been shown that, when superparamagnetic iron oxide nanoparticles are coated with bovine serum albumin and further conjugated with folic acid, which is a tumor-specific ligand, it can be used for tumor-targeted contrasting agents. Further labelling with fluorescein isothiocyanate enabled also intracellular visualization [17,100]. Magnetic characteristics of inorganic nanoparticles can also be used in treatment through the induction of hyperthermia.…”

Section: Nanomaterials and Brain Cancermentioning

confidence: 99%

Nanotechnology Meets Oncology: Nanomaterials in Brain Cancer Research, Diagnosis and Therapy

2019

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Advances in technology of the past decades led to development of new nanometer scale diagnosis and treatment approaches in cancer medicine leading to establishment of nanooncology. Inorganic and organic nanomaterials have been shown to improve bioimaging techniques and targeted drug delivery systems. Their favorable physico-chemical characteristics, like small sizes, large surface area compared to volume, specific structural characteristics, and possibility to attach different molecules on their surface transform them into excellent transport vehicles able to cross cell and/or tissue barriers, including the blood–brain barrier. The latter is one of the greatest challenges in diagnosis and treatment of brain cancers. Application of nanomaterials can prolong the circulation time of the drugs and contrasting agents in the brain, posing an excellent opportunity for advancing the treatment of the most aggressive form of the brain cancer—glioblastomas. However, possible unwanted side-effects and toxicity issues must be considered before final clinical translation of nanoparticles.

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Section: Nanomaterials and Brain Cancermentioning

confidence: 99%

Nanotechnology Meets Oncology: Nanomaterials in Brain Cancer Research, Diagnosis and Therapy

2019

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“…Therefore, silica shells double-coated with semiconducting polymer layers were synthesized for fluorescence and photoacoustic brightness imaging [79]. Moreover, phosphonate polyethylene glycol and cyclo RGD functionalized iron-oxide nanoparticles [80] or bovine serum albumin and tumor-specific folic acid [81] functionalized iron-oxide nanoparticles were applied for magnetic resonance imaging. Another strategy for the diagnosis of glioblastoma involves coating gold nanoparticles with the CBP4 peptide for an enhanced binding to the CD133 biomarker [82].…”

Section: Nanomedicine In Central Nervous System Disordersmentioning

confidence: 99%

Neuronanomedicine: An Up-to-Date Overview

et al. 2019

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The field of neuronanomedicine has recently emerged as the bridge between neurological sciences and nanotechnology. The possibilities of this novel perspective are promising for the diagnosis and treatment strategies of severe central nervous system disorders. Therefore, the development of nano-vehicles capable of permeating the blood–brain barrier (BBB) and reaching the brain parenchyma may lead to breakthrough therapies that could improve life expectancy and quality of the patients diagnosed with brain disorders. The aim of this review is to summarize the recently developed organic, inorganic, and biological nanocarriers that could be used for the delivery of imaging and therapeutic agents to the brain, as well as the latest studies on the use of nanomaterials in brain cancer, neurodegenerative diseases, and stroke. Additionally, the main challenges and limitations associated with the use of these nanocarriers are briefly presented.

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“…Hence, studies report the use of iron oxide nanoparticles functionalized with phosphonate polyethylene glycol and covalently coupled to the cyclo RGD peptide sequence as magnetic resonance imaging contrast agents due to their magnetic properties [37]. Furthermore, by coating the iron oxide nanoparticles with bovine serum albumin, conjugating the tumor-specific ligand folic acid onto them, and labeling with fluorescein isothiocyanate, an enhanced intracellular dual-modal imaging, specifically the magnetic resonance imaging and intracellular visualization, for brain tumors can be obtained [38]. Alternatively, multilayered semiconducting polymer nanoparticles containing a hydrophobic semiconducting polymer that was coated with an optically inner silica shell have been synthetized for brain tumors imaging using both fluorescence and photoacoustic brightness [39].…”

Section: The Use Of Nanoparticles For the Diagnosis And Treatment mentioning

confidence: 99%

Impact of Nanoparticles on Brain Health: An Up to Date Overview

Teleanu

Chircov

Grumezescu

et al. 2018

JCM

151

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Nanoparticles are zero-dimensional nanomaterials and, based on their nature, they can be categorized into organic, inorganic, and composites nanoparticles. Due to their unique physical and chemical properties, nanoparticles are extensively used in a variety of fields, including medicine, pharmaceutics, and food industry. Although they have the potential to improve the diagnosis and treatment of brain diseases, it is fundamentally important to develop standardized toxicological studies, which can prevent the induction of neurotoxic effects. The focus of this review is to emphasize both the beneficial and negative effects of nanoparticles on brain health.

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Synthesis of tumor-targeted folate conjugated fluorescent magnetic albumin nanoparticles for enhanced intracellular dual-modal imaging into human brain tumor cells

Cited by 50 publications

References 46 publications

Nanotechnology Meets Oncology: Nanomaterials in Brain Cancer Research, Diagnosis and Therapy

Nanotechnology Meets Oncology: Nanomaterials in Brain Cancer Research, Diagnosis and Therapy

Neuronanomedicine: An Up-to-Date Overview

Impact of Nanoparticles on Brain Health: An Up to Date Overview

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