Synthesis of Tropinones by Cyclization of 1,3‐Bis‐Silyl Enol Ethers with Iminium Triflates.

Abstract

Triflates. -The 1,3-bis-silyl enol ether (I) reacts with the 2-methoxypyrrolidine (II) to afford the expected condensation product (III) in the presence of Tms-O-Tf. Extension of the reaction to the dialkoxy derivatives (V) and (VII) results in formation of bicyclic 1,3-dicarbonyl compounds. -(ALBRECHT, U.; ARMBRUST, H.; LANGER*, P.; Synlett 2004, 1, 143-145; Inst. Chem. Biochem.,