Synthesis of tritiated N-[4-(2,4-diaminopteridine-6-methyl)-3,4-dihydro-2H-1,4-benzothiazine-7-carbonyl]-L-homo glutamic acid (MX-68)

Abstract

Synthesis of tritiated N‐[4‐(2,4‐diaminopteridine‐6‐methyl)‐3,4‐dihydro‐2H‐1,4‐benzothiazine‐7‐carbonyl]‐L‐homoglutamic acid, [9‐3H1]MX‐68 (3), is described. [9‐3H1]MX‐68 (3) was prepared via tritiation at the carbonyl group in 2,4‐bis‐(butanoylamino)‐6‐formylpteridine (7) with sodium borotritiide. © 1997 John Wiley & Sons, Ltd.