Synthesis of trifluoromethylated pyrazoles from trifluoromethylenaminones and monosubstituted hydrazines

The crystal structure of ethyl 1-(4-nitrophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate, C13H10F3N3O4

“…As a part of our ongoing interest on the synthesis, physico-chemical and structural properties of the pyrazole based coordination compounds [12,13] we examined the crystal structure of the title pyrazole ligand. The bond lengths and angles within the Nphenylpyrazole core are comparable with those reported for the similar pyrazole ligands [14][15][16][17][18]. The C1-N1 bond [1.436(2) Å] allows a rotation of the phenyl relative to the pyrazole ring, thus the dihedral angle between the corresponding ring planes is 49.26(6)°.…”

Synergic Effects of Ionic Liquid and Microwave Irradiation in Promoting Trifluoromethylpyrazole Synthesis

“…Substituted pyrazoles are important synthetic targets in the pharmaceutical industry because the pyrazole motif makes up the core structure of numerous biologically active compounds, including blockbuster drugs such as Celecoxib [17] and Sildenafil [18]. Although several methods have been developed, regioselective synthesis of the pyrazole ring remains a significant challenge for organic chemists [19][20][21][22]. In this context, our aim in this work is to demonstrate the synergic effects of ionic liquid and microwave irradiation in promoting the synthesis of trifluoromethyl pyrazoles.…”

Microwave-assisted synthesis of fused heterocycles incorporating trifluoromethyl moiety

“…Their versatility and effectiveness as potential multicomponent substrates have been proven to be building blocks for a wide variety of trifluoromethyl-substituted heterocyles. These include pyrazoles [32][33][34], pyridines [35], pyrimidines [36], isoxazoles [37], and thiazoles [38]. However, most of the thermal syntheses of such compounds consume a lot of time and/or lake of high selectivity.…”