Synthesis of Trifluoromethylated Pyrazoles from Trifluoromethylenaminones and Monosubstituted Hydrazines.

Abstract

Pyrazole derivatives R 0180Synthesis of Trifluoromethylated Pyrazoles from Trifluoromethylenaminones and Monosubstituted Hydrazines. -Reaction of monosubstituted hydrazines (II) with trifluoroenaminoes (I) and (V) affords 3-CF 3 and/or 5-CF 3 pyrazoles in most cases as mixtures of regioisomers. -(TOUZOT, A.; SOUFYANE, M.; BERBER, H.; TOUPET, L.; MIRAND*, C.; J. Fluorine Chem. 125 (2004) 9, 1299-1304; Fac. Pharm., CNRS, Univ. Reims-Champagne-Ardenne, F-51096 Reims, Fr.; Eng.) -M. Paetzel 02-105