Synthesis of Triazolylisatins Glycoconjugates and Some Ammonium Hydrazones on Their Basis

Богданов, А. В.; Andreeva, O. V.; Belenok, M. G.; Voloshina, Alexandra D.; Enikeeva, Kadriia; Самородов, Александр В.; Миронов, В. Ф.

doi:10.1134/s1070363221070045

Cited by 5 publications

(5 citation statements)

References 43 publications

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“…One of the groups of biologically active substances contained in hawthorn and of practical interest are lipophilic substances (essential oils, sterols, fatty acids, pigments, and others). It is worth noting a wide range of their pharmacological characteristics, such as antiatherosclerotic, hypolipidemic, wound healing, antibacterial and antioxidant effects [6][7][8][9][10][11][12][13]. All this confirms the expediency of isolation, identification and further studies of lipophilic substances contained in plant materials in order to expand the range of herbal products.…”

Section: Introductionmentioning

confidence: 92%

“…There is evidence of the clinical use of hawthorn extracts as an adjuvant therapy in chronic heart failure, an antiarrhythmic effect of both fruits and extracts from hawthorn shoots has been noted. The hypotensive potential of hawthorn phenolic fractions has been studied in vitro, in animal models and in clinical studies [6][7][8][9][10][11][12][13]. Each type of plant material is characterized by the accumulation of a large number of groups of biologically active substances with a variety of biological properties.…”

Section: Introductionmentioning

confidence: 99%

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Chemical Composition of Lipophilic Fractions of Raw Material Crataegus Rivularis Nutt

Enikeeva

Хасанова

Кудашкина

et al. 2022

JPRI

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Aims: study of the composition of lyophilic substances in the raw materials of Crataegus rivularis Nutt. Study Design: experimental laboratory studies of dry plant materials. Place and Duration of Study: Bashkir State Medical University, Izhevsk State Medical Academy, Volga Research Medical University and Ural Branch of the Russian Academy of Sciences from August 2021 to May 2022. Methodology: Using gas chromatography with a mass-selective detector, lipophilic fractions of the fruits, shoots, flowers, leaves and fruits of riverine hawthorn, harvested in 2021 in the South Ural Botanical Garden-Institute, were studied. Results: In general, the shoots and leaves of Crataegus rivularis accumulate compounds of the class of steroids, phytosterols, terpenoids, saponins and phenolic compounds, which suggests that the raw material may have additional pharmacological properties, such as hypocholesterolemic and antioxidant. Conclusion: The results obtained show the good prospects for further studies of the composition of hawthorn extracts to expand the possibilities of phytotherapy.

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Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Chemical Composition of Lipophilic Fractions of Raw Material Crataegus Rivularis Nutt

Enikeeva

Хасанова

Кудашкина

et al. 2022

JPRI

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“…The synthesis of target compounds is based on our previously developed approach [24][25][26][27][28][29][30] and is carried out in two stages (Fig. 1).…”

Section: Chemistrymentioning

confidence: 99%

“…In recent years, our research group has been working in this direction, namely in the synthesis and study of the antimicrobial activity of water-soluble isatin hydrazones containing a positively charged nitrogen atom (Fig. 2) [24][25][26][27][28][29][30]. Those studies showed the dependence of antimicrobial activity on many structural factors.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and diverse biological activity profile of triethylammonium isatin-3-hydrazones

Богданов¹,

Tsivileva²,

Voloshina³

et al. 2022

ADMET DMPK

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A series of biorelevant triethylammonium isatin hydrazones containing various substituents in the aromatic fragment have been synthesized. Their structure and composition were confirmed by NMR- and IR-spectroscopies, mass-spectrometry and elemental analysis. It was found that some representatives show activity against Staphylococcus aureus and Bacillus cereus higher or at the level of norfloxacin, including methicillin-resistant Staphylococcus aureus strains. The study also showed low hemo- and cytotoxicity (Chang Liver) and high antiaggregatory and anticoagulant activity of these compounds. The high potential of new ammonium isatin-3-acylhydrazones in the search for antimicrobial activity against phytopathogens of bacterial and fungal nature has been shown for the first time.

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“…Phytotherapy of various diseases is regulated by the licensing documentation of health authorities and is included in conventional medicine [1]. The basis of medicines that are used in modern phytotherapy are water extracts of flowers and stems of plants devoid of poisonous and potent compounds, therefore these infusions and teas have good tolerability and low frequency of side effects compared with synthetic drugs [2][3][4]. The fact is that the safety of the plants used has been confirmed by their safe ingestion by various representatives of the animal world for many millions of years.…”

Section: Introductionmentioning

confidence: 99%

Herbal Infusions and Teas Taken Orally: What is not Taken into Account in the Phytotherapy of Type 2 Diabetes Mellitus

Urakov¹,

Уракова²,

Shchemeleva³

et al. 2022

JPRI

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Infusions, decoctions and teas made from hot drinking water and various medicinal plants are widely used in folk medicine and pharmacy in the Russian Federation and in the countries of Southwest Asia. In this study, the methods of ethnopharmacology and pharmacy were combined to clarify the mechanism of action of traditional herbal mixtures in the phytotherapy of type 2 diabetes mellitus. The technology of preparation of infusions, decoctions and teas from medicinal plants and the quality of water are analyzed. It is shown that the traditional assessment of the pharmacological activity of herbal mixtures was previously considered only from the point of view of the biological activity of the main chemical components, without taking into account the influence of water, its volume, as well as without taking into account acidic, osmotic (hypotonic) activity and temperature of water extracts. However, it has been shown that drinking water is also the main active ingredient of water extracts, and the quality of water and its physical-chemical properties can be important in the effect on the body of patients. In particular, attention is drawn to the fact that ingestion of 250 ml of such aqueous extracts can dilute blood plasma, reduce the concentration of all substances in it, including glucose concentration, reduce osmotic activity of the plasma and promote the removal of glucose from the body due to its "washing". Therefore, traditional herbal medicine based on ingestion of 250 ml of aqueous extracts 2-4 times a day may be accompanied by hypoglycemia and a decrease in the concentration of all other ingredients in the blood plasma not so much due to the action of biologically active substances, but also due to the action of water. The process of reducing the concentration of glucose in the blood is more intense and significant, the faster the water is absorbed into the blood and the more water is drunk. It is also obvious that some of the glucose is excreted with water from the body during urination and sweating. Nevertheless, in order to give a definitive answer to the role of herbal teas and infusions in the phytotherapy of diabetes mellitus, new and more comprehensive pharmacological studies are required in the future, taking into account the volume of water and the physico-chemical properties of water extracts.

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Synthesis of Triazolylisatins Glycoconjugates and Some Ammonium Hydrazones on Their Basis

Cited by 5 publications

References 43 publications

Chemical Composition of Lipophilic Fractions of Raw Material Crataegus Rivularis Nutt

Chemical Composition of Lipophilic Fractions of Raw Material Crataegus Rivularis Nutt

Synthesis and diverse biological activity profile of triethylammonium isatin-3-hydrazones

Herbal Infusions and Teas Taken Orally: What is not Taken into Account in the Phytotherapy of Type 2 Diabetes Mellitus

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