Synthesis of Tri-Substituted Olefin Derivatives from 1-Alkene-1,2-Diboronic Esters via Sequential Suzuki-Suzuki Coupling Reaction and Their Biological Activity

Regio- and stereocontrolled synthesis of borylated E-enynes, Z-enediynes and derivatives from alkenyl-1,2-bis-(boronates)

“…24 We also demonstrated regioselective azidations 25 and synthesis of trisubstituted olefin derivatives from 1-alkene-1,2-diboronic esters. 26 Here we describe a simple method using a palladium catalyst to form E -enynes and Z -enediynes via Suzuki–Miyaura cross-coupling reactions between bis-boronic esters and alkynyl halides (Scheme 1e).…”