Synthesis of titanium oxide nanoparticles using Aloe barbadensis mill and evaluation of its antibiofilm potential against Pseudomonas aeruginosa PAO1

Phyto-Mediated Synthesis of Porous Titanium Dioxide Nanoparticles From Withania somnifera Root Extract: Broad-Spectrum Attenuation of Biofilm and Cytotoxic Properties Against HepG2 Cell Lines

“…Biofilm inhibition upon treatment with 0.5 × MIC of TiO 2 NPs was observed under confocal laser scanning microscope (CLSM) as previously described ( Rajkumari et al, 2019 ).…”

“…In recent years, bioinspired fabrication of NPs using various biological systems, such as microorganisms ( Oves et al, 2019 ) and plants ( Al-Shabib et al, 2016 , 2018b ), has gained momentum. The plant-mediated NP synthesis has generated lot of interest due to the wide availability of the plants; safe, clean, and eco-friendly synthesis; and low energy consumption ( Rajkumari et al, 2019 ). Aqueous extracts of various plant parts, including seeds, roots, leaves, stems, and fruits have been used for metallic NP synthesis.…”

“…The biomediated production of TiO 2 NPs has found application in disease treatment, surgical product manufacture, photocatalysis, tissue engineering, agriculture, and cosmetics ( Nadeem et al, 2018 ). Various plants and their parts have been reported for the production of TiO 2 NPs, including Acanthophyllum laxiusculum (roots), Aloe barbadensis (leaves), Annona squamosa (peel), Calotropis gigantea (flower), Cicer arietinum (seeds), and Dandelion (pollen) ( Marimuthu et al, 2013 ; Bao et al, 2012 ; Roopan et al, 2012 ; Kashale et al, 2016 ; Madadi and Lotfabad, 2016 ; Rajkumari et al, 2019 ).…”

Metal Oxide Nanoparticles Against Bacterial Biofilms: Perspectives and Limitations

“…Exposure to titanium oxide leads to the destruction of bacteria inside the biofilm, primarily due to the generation of ROS and lipid oxidation on the cell wall membrane [ 92 , 120 ]. It has been shown that TiO 2 NPs are effective against biofilms of MRSA [ 92 ] and S. mitis [ 125 ]. TiO 2 NPs could control the growth and biofilm formation of S. mitis ATCC 6249 and Ora-20, and it can be used as a means for oral hygiene.…”

“…TiO 2 NPs could control the growth and biofilm formation of S. mitis ATCC 6249 and Ora-20, and it can be used as a means for oral hygiene. TiO 2 NPs have a reduced impact on Pseudomonas aeruginosa biofilms at a 31.25 µg/mL concentration and disrupt previously established biofilms in the microtiter plate [ 125 ]. In the presence of TiO 2 NPs, biofilm formation of E. coli and B. subtilis was reduced by 40–50% [ 122 ].…”