Synthesis of TiO2 nanostructured reservoir with temozolomide: Structural evolution of the occluded drug

Treatment of Parkinson's disease: nanostructured sol–gel silica–dopamine reservoirs for controlled drug release in the central nervous system

“…This was followed by a calculation of the single point-to-point energy in order to identify the most stable energy state, the electrostatic potential associated with the molecule, and the characteristic Fukui potentials, as previously reported. 28 …”

Cortisol controlled release by mesoporous silica

“…[8][9][10] Drug carriers are made of polymer hydrogels [1][2][3][4][5]11,12 or of inorganic ceramic materials. [13][14][15][16][17][18][19][20][21][22][23] Drug delivery to the central nervous system has been a challenging area of research because of the restrictions imposed by the blood-brain barrier. This has led to different approaches to the transport of drugs to the brain, including microencapsulation with polymer hydrogels [1][2][3][4][5] and inorganic reservoirs that are placed in the brain.…”

“…This has led to different approaches to the transport of drugs to the brain, including microencapsulation with polymer hydrogels [1][2][3][4][5] and inorganic reservoirs that are placed in the brain. [13][14][15][16][17][18][19][20] In particular, ceramic types of reservoirs have been developed for long-term therapies of epilepsy [13][14][15][16][17][18] and alternative therapies of brain tumors. 19,20 In all these studies, pore size and surface functionalization have played an important role in the kinetics of drug delivery.…”

“…[13][14][15][16][17][18][19][20] In particular, ceramic types of reservoirs have been developed for long-term therapies of epilepsy [13][14][15][16][17][18] and alternative therapies of brain tumors. 19,20 In all these studies, pore size and surface functionalization have played an important role in the kinetics of drug delivery. In this sense, functionalized ordered mesoporous silica materials such as SBA-15, because of its highly ordered pore structure, large specific surface area, and controllable pore dimension, play an important role in drug delivery applications.…”

Effect of textural properties on the drug delivery behaviour of nanoporous TiO2 matrices

“…Lopez et al [18] have investigated a sol-gel synthesized nanostructured TiO2 matrix with different channel size as reservoirs for the controlled delivery of Temozolomide, an important drug for the treatment of tumors.…”