Synthesis of thiazolo[3,2-a]pyrimidine molecules, in vitro cytotoxic evaluation and molecular docking studies

Synthesis of Imidazole‐2,3‐dihydrothiazole Compounds as VEGFR‐2 Inhibitors and Their Support with in Silico Studies

“…were determined on the Mettler Toledo-MP90 Melting Point System and were uncorrected. 1 H-NMR (nuclear magnetic resonance) Bruker DPX 300 FT-NMR spectrometer; 13 C-NMR, Bruker DPX 75 MHz spectrometer (Bruker Bioscience, Billerica, MA, USA). Mass spectra were recorded on a LCMS-IT-TOF (Shimadzu, Kyoto, Japan) using ESI.…”

“…À CH 2 À ), 6.43 (1H, s, thiazole), 7.41 (1H, m, monosubstituted benzene), 7.50 (2H, m, p-disubstituted benzene), 7.57 (2H, s, pdisubstituted benzene), 7.59 (1H, m, Imidazole), 7.73 (2H, m, monosubstituted benzene), 7.80 (4H, m, p-disubstituted benzene), 8.01 (2H, d, J = 8.71, p-substituted benzene), 8.08 (1H, m, Imidazole), 9.07 (1H, s, Imidazole). 13…”

“…Finally, the target compounds (4a-4l) were obtained using ring closure reaction. The structures of the obtained compounds were evaluated by spectroscopic methods, namely 1 H-NMR, 13 C-NMR, and HR-MS (Supplementary Data).…”

“…The thiazole ring is very useful in terms of biological activity. There is a lot of literature information showing its anticancer and antifungal activity [10–17] . In addition to this information, there is also a study using the thiazole ring as a VEGFR‐2 inhibitor [18] .…”

“…There is a lot of literature information showing its anticancer and antifungal activity. [10][11][12][13][14][15][16][17] In addition to this information, there is also a study using the thiazole ring as a VEGFR-2 inhibitor. [18] When docking studies are examined, the interaction of the thiazole ring with Asp1046, which is an important amino acid for the enzyme, shows the potential of the ring to inhibit VEGFR-2.…”