Synthesis of thermosensitive micelles based on poly(N-isopropylacrylamide) and poly(l-alanine) for controlled release of adriamycin

Pan, Qiao; Niu, Qinsu; Wang, Zhibin; Cao, Dapeng

doi:10.1016/j.cej.2010.02.035

Cited by 37 publications

(17 citation statements)

References 44 publications

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“…Poly( N -isopropylacrylamide) (pNIPAAm) gel, as one of the most widely studied temperature-responsive polymers [9-11], undergoes phase transition in water when the temperature increases or decreases beyond its lower critical solution temperature (LCST; approximately 32°C) [12,13]. Besides, its LCST can be tuned by the addition of a comonomer during polymerization [14,15].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of NIR-responsive Aurod@pNIPAAm-PEGMA nanogels as vehicles for delivery of photodynamic therapy agents

et al. 2013

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A near-infrared (NIR)-responsive Aurod@pNIPAAm-PEGMA nanogel was synthesized in two steps, growing a PEGMA monolayer on the surface of gold nanorods (AuNRs), followed by in situ polymerization and cross-linking of N-iso-propylacrylamide (NIPAAm) and poly-(ethylene glycol)-methacrylate (PEGMA). The AuNRs and Aurod@pNIPAAm-PEGMA nanogel were characterized by UV–vis spectroscopy, Raman spectroscopy, Fourier transform infrared spectroscopy, and transmission electron microscopy, respectively. The lower critical solution temperature of the Aurod@pNIPAAm-PEGMA nanogel could be tuned by changing the molar ratio of NIPAAm/PEGMA. The NIR-mediated drug release behavior of the Aurod@pNIPAAm-PEGMA nanogel was studied with zinc phthalocyanines (ZnPc4) as a drug model. It was also demonstrated that the loaded ZnPc4 could keep the capability of generating singlet oxygen, and the in vitro study showed a great photodynamic therapy (PDT) effect on Hela cells. It thus indicated the potential of this Aurod@pNIPAAm-PEGMA nanogel for application as a drug carrier in PDT, which might make contributions to oncotherapy.

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Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of NIR-responsive Aurod@pNIPAAm-PEGMA nanogels as vehicles for delivery of photodynamic therapy agents

et al. 2013

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“…68–73 In addition to traditional synthetic thermoresponsive polymers such as poly(N-isopropylacrylamide) (PNIPAAM), 74–78 (poly)peptides with desired thermoresponsiveness such as elastin-like polypeptides (ELPs) have also been reported. 79–83 The characteristic, easily tunable, LCST-like inverse temperature transition of this class of polypeptides 79, 84 provides ELPs with the ability to be used as building blocks for thermoresponsive smart biomaterials.…”

Section: Resultsmentioning

confidence: 99%

Thermoresponsive Elastin-b-Collagen-Like Peptide Bioconjugate Nanovesicles for Targeted Drug Delivery to Collagen-Containing Matrices

Luo¹,

David²,

Dunshee³

et al. 2017

Biomacromolecules

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Over the past few decades, (poly)peptide block copolymers have been widely employed in generating well-defined nanostructures as vehicles for targeted drug delivery applications. We previously reported the assembly of thermoresponsive nanoscale vesicles from an elastin-b-collagen like peptide (ELP-CLP). The vesicles were observed to dissociate at elevated temperatures, despite the LCST-like behavior of the tethered ELP domain, which is suggested to be triggered by the unfolding of the CLP domain. Here, the potential of using the vesicles as drug delivery vehicles for targeting collagen-containing matrices is evaluated. The sustained release of an encapsulated model drug was achieved over a period of three weeks, following which complete release could be triggered via heating. The ELP-CLP vesicles show strong retention on a collagen substrate, presumably through collagen triple helix interactions. Cell viability and proliferation studies using fibroblasts and chondrocytes suggest that the vesicles are highly cytocompatible. Additionally, essentially no activation of a macrophage-like cell line is observed, suggesting that the vesicles do not initiate an inflammatory response. Endowed with thermally controlled delivery, the ability to bind collagen, and excellent cytocompatibility, these ELP-CLP nanovesicles are suggested to have significant potential in the controlled delivery of drugs to collagen-containing matrices and tissues.

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“…The core of the hydrophobic portion activated the adsorptive linking of the benzene aromatic ring and localized the hydrophobic interaction. The hydrophilic shell protects the inner hydrophobic core, thereby, avoiding further interaction of the core with the surrounding environment (Qiao et al 2010). …”

Section: Encapsulation Of Benzene Into Copolymermentioning

confidence: 98%

Removal of Benzene Using the Characteristics of Block Copolymers for Encapsulation

Choi

Chung

Baek

et al. 2011

Water Air Soil Pollut

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This study assessed the aqueous benzene removal capacity of a polymeric adsorbent, based on an amphiphilic material, in a batch experiment. Two types of polystyrene-block-poly(N-isopropylacrylamide) have structures containing a hydrophobic core and hydrophilic shell. The encapsulation mechanism of benzene by a polymeric adsorbent was investigated, and found to be attributable to the Van der Waals interactions between the benzene aromatic ring and the hydrophobic core of the adsorbent. The equilibrium data were analyzed using the Langmuir and Freundlich adsorption isotherms, and found to be a good fit to both. The maximum adsorption capacity for benzene by the polymeric adsorbent was found to be 194.53 mg/g. The kinetic data followed a pseudo-first-order kinetic model. Polystyreneblock-poly(N-isopropylacrylamide) showed the potential to be an effective adsorbent for application to wastewater treatment.

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Synthesis of thermosensitive micelles based on poly(N-isopropylacrylamide) and poly(l-alanine) for controlled release of adriamycin

Cited by 37 publications

References 44 publications

Synthesis and characterization of NIR-responsive Aurod@pNIPAAm-PEGMA nanogels as vehicles for delivery of photodynamic therapy agents

Synthesis and characterization of NIR-responsive Aurod@pNIPAAm-PEGMA nanogels as vehicles for delivery of photodynamic therapy agents

Thermoresponsive Elastin-b-Collagen-Like Peptide Bioconjugate Nanovesicles for Targeted Drug Delivery to Collagen-Containing Matrices

Removal of Benzene Using the Characteristics of Block Copolymers for Encapsulation

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